Cell Senescence Entries for SGK1

Cell Types
Umbilical vein endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Umbilical vein endothelial cells overexpressing full-length SGK1 showed a decrease in SA-beta-galactosidase and p21 expression and a corresponding increase in hTERT activity in the early stages of aging.
Primary Reference

    SGK1 Gene Information

    HGNC symbol
    SGK1 
    Aliases
    SGK 
    Common name
    serum/glucocorticoid regulated kinase 1 
    Entrez Id
    6446
    Description
    This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

    SGK1 Ontologies

    Gene Ontology
    Process: GO:6915; apoptotic process
    GO:6974; cellular response to DNA damage stimulus
    GO:35556; intracellular signal transduction
    GO:34220; ion transmembrane transport
    GO:7616; long-term memory
    GO:48812; neuron projection morphogenesis
    GO:18105; peptidyl-serine phosphorylation
    GO:32411; positive regulation of transporter activity
    GO:6468; protein phosphorylation
    GO:42981; regulation of apoptotic process
    GO:8217; regulation of blood pressure
    And 10 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5789; endoplasmic reticulum membrane
    GO:5739; mitochondrion
    GO:16607; nuclear speck
    GO:5634; nucleus
    GO:5886; plasma membrane
    Function: GO:5524; ATP binding
    GO:5246; calcium channel regulator activity
    GO:17081; chloride channel regulator activity
    GO:15459; potassium channel regulator activity
    GO:5515; protein binding
    GO:4674; protein serine/threonine kinase activity
    GO:4712; protein serine/threonine/tyrosine kinase activity
    GO:17080; sodium channel regulator activity
    Show all GO terms

    Homologs of SGK1 in Model Organisms

    Danio rerio
    sgk1
    Mus musculus
    Sgk1
    Rattus norvegicus
    Sgk1

    In other databases

    GenAge microarray genes
    • This gene is present as SGK1
    LongevityMap
    • This gene is present as SGK1

    External links

    OMIM
    602958
    Ensembl
    ENSG00000118515
    Entrez Gene
    6446
    UniGene
    510078
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SGK1
    GeneCards
    SGK1