Cell Senescence Entries for SERPINE1

Cell Types
Foreskin fibroblast
Cell Lines
Primary cell, BJ
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
RNA interference of PAI-1 (SERPINE1), a p53 target, lead to escape from replicative senescence in primary foreskin fibroblasts (BJ cells). Moreover, expression of PAI-1 in p53-knockdown cells restored cellular senescence, as observed by a flat-cell morphology and positive staining for SA-beta-galactosidase.
Primary Reference

    SERPINE1 Gene Information

    HGNC symbol
    SERPINE1 
    Aliases
    PAI; PAI1; PAI-1; PLANH1 
    Common name
    serpin family E member 1 
    Entrez Id
    5054
    Description
    This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

    SERPINE1 Ontologies

    Gene Ontology
    Process: GO:1525; angiogenesis
    GO:71222; cellular response to lipopolysaccharide
    GO:1300; chronological cell aging
    GO:7623; circadian rhythm
    GO:50829; defense response to Gram-negative bacterium
    GO:30198; extracellular matrix organization
    GO:42730; fibrinolysis
    GO:30195; negative regulation of blood coagulation
    GO:33629; negative regulation of cell adhesion mediated by integrin
    GO:30336; negative regulation of cell migration
    GO:10951; negative regulation of endopeptidase activity
    And 19 more GO terms
    Cellular component: GO:70062; extracellular exosome
    GO:31012; extracellular matrix
    GO:5576; extracellular region
    GO:5615; extracellular space
    GO:5886; plasma membrane
    GO:31093; platelet alpha granule lumen
    Function: GO:2020; protease binding
    GO:5515; protein binding
    GO:5102; receptor binding
    GO:4867; serine-type endopeptidase inhibitor activity
    Show all GO terms

    Homologs of SERPINE1 in Model Organisms

    Caenorhabditis elegans
    srp-3
    Danio rerio
    serpine1
    Mus musculus
    Serpine1
    Rattus norvegicus
    Serpine1

    In other databases

    GenAge human genes
    LongevityMap

    External links

    OMIM
    173360
    Ensembl
    ENSG00000106366
    Entrez Gene
    5054
    UniGene
    414795
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    SERPINE1
    GeneCards
    SERPINE1