Cell Senescence Entries for RPS6KA6

Cell Types
Colon cancer, Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Overexpression of RSK4 (RPS6KA6) induced cell arrest and cell senescence features (including morphogenic changes, increased SA-beta-galactosidase activity, increased SA-heterochromatin foci and an increase in p21 and p16 markers) both in normal fibroblasts and malignant colon carcinoma cell lines. Contrastly, RSK4 inhibition induced resistance to cellular senescence.
Primary Reference

    RPS6KA6 Gene Information

    HGNC symbol
    RPS6KA6 
    Aliases
    RSK4; RSK-4; p90RSK6; PP90RSK4; S6K-alpha-6 
    Common name
    ribosomal protein S6 kinase A6 
    Entrez Id
    27330
    Description
    This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010]

    RPS6KA6 Ontologies

    Gene Ontology
    Process: GO:6978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
    GO:7417; central nervous system development
    GO:70373; negative regulation of ERK1 and ERK2 cascade
    GO:45992; negative regulation of embryonic development
    GO:2000381; negative regulation of mesoderm development
    GO:6468; protein phosphorylation
    GO:7165; signal transduction
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:1650; fibrillar center
    GO:5739; mitochondrion
    GO:5730; nucleolus
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:5524; ATP binding
    GO:16301; kinase activity
    GO:287; magnesium ion binding
    GO:4672; protein kinase activity
    GO:4674; protein serine/threonine kinase activity
    Show all GO terms

    Homologs of RPS6KA6 in Model Organisms

    Caenorhabditis elegans
    rskn-1
    Danio rerio
    rps6ka6
    Drosophila melanogaster
    S6kII
    Mus musculus
    Rps6ka6
    Rattus norvegicus
    Rps6ka6
    Schizosaccharomyces pombe
    sck1

    External links

    OMIM
    300303
    Ensembl
    ENSG00000072133
    Entrez Gene
    27330
    UniGene
    234478
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    RPS6KA6
    GeneCards
    RPS6KA6