Cell Senescence Entries for RBX1

Cell Types
Glioblastoma, Lung cancer
Cell Lines
U87
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
RNA interference of ROC1 (RBX1), which is overexpressed in a number of human cancer cell lines, significantly inhibited the growth of these cells via induction of senescence and apoptosis as well as G(2)-M arrest.
Primary Reference

    RBX1 Gene Information

    HGNC symbol
    RBX1 
    Aliases
    ROC1; RNF75; BA554C12.1 
    Common name
    ring-box 1 
    Entrez Id
    9978
    Description
    This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]

    RBX1 Ontologies

    Gene Ontology
    Process: GO:42769; DNA damage response, detection of DNA damage
    GO:165; MAPK cascade
    GO:10265; SCF complex assembly
    GO:31146; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
    GO:16055; Wnt signaling pathway
    GO:70911; global genome nucleotide-excision repair
    GO:10972; negative regulation of G2/M transition of mitotic cell cycle
    GO:90090; negative regulation of canonical Wnt signaling pathway
    GO:715; nucleotide-excision repair, DNA damage recognition
    GO:717; nucleotide-excision repair, DNA duplex unwinding
    GO:33683; nucleotide-excision repair, DNA incision
    And 13 more GO terms
    Cellular component: GO:31462; Cul2-RING ubiquitin ligase complex
    GO:31463; Cul3-RING ubiquitin ligase complex
    GO:31464; Cul4A-RING E3 ubiquitin ligase complex
    GO:31465; Cul4B-RING E3 ubiquitin ligase complex
    GO:31466; Cul5-RING ubiquitin ligase complex
    GO:31467; Cul7-RING ubiquitin ligase complex
    GO:19005; SCF ubiquitin ligase complex
    GO:30891; VCB complex
    GO:31461; cullin-RING ubiquitin ligase complex
    GO:5829; cytosol
    GO:5654; nucleoplasm
    And 1 more GO terms
    Function: GO:19788; NEDD8 transferase activity
    GO:97602; cullin family protein binding
    GO:16874; ligase activity
    GO:5515; protein binding
    GO:32403; protein complex binding
    GO:61630; ubiquitin protein ligase activity
    GO:31625; ubiquitin protein ligase binding
    GO:4842; ubiquitin-protein transferase activity
    GO:34450; ubiquitin-ubiquitin ligase activity
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of RBX1 in Model Organisms

    Caenorhabditis elegans
    rbx-1
    Danio rerio
    rbx1
    Drosophila melanogaster
    Roc1a
    Mus musculus
    Rbx1
    Rattus norvegicus
    Rbx1
    Saccharomyces cerevisiae
    HRT1
    Schizosaccharomyces pombe
    pip1

    External links

    OMIM
    603814
    Ensembl
    ENSG00000100387
    Entrez Gene
    9978
    UniGene
    474949
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    RBX1
    GeneCards
    RBX1