Cell Senescence Entries for RBP2

Cell Types
Cervical cancer, Gastric cancer
Cell Lines
AGS, BGC-823, HGC-27, KATO-III, HeLa, SiHa
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
In gastric and cervical cancer cells, RBP2-depletion induced cellular senescence, including growth arrest, diminished foci numbers and elevated expression of cyclin-dependent kinase inhibitors p21, p27 and p16.
Primary Reference

    RBP2 Gene Information

    HGNC symbol
    RBP2 
    Aliases
    CRBP2; RBPC2; CRBPII; CRABP-II 
    Common name
    retinol binding protein 2 
    Entrez Id
    5948
    Description
    This gene encodes an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. This protein may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Aug 2015]

    RBP2 Ontologies

    Gene Ontology
    Process: GO:8544; epidermis development
    GO:1523; retinoid metabolic process
    GO:6810; transport
    GO:6776; vitamin A metabolic process
    Cellular component: GO:5829; cytosol
    Function: GO:16918; retinal binding
    GO:5501; retinoid binding
    GO:19841; retinol binding
    GO:5215; transporter activity
    Show all GO terms

    Homologs of RBP2 in Model Organisms

    Danio rerio
    rbp2a
    Mus musculus
    Rbp2
    Rattus norvegicus
    Rbp2

    External links

    OMIM
    180280
    Ensembl
    ENSG00000114113
    Entrez Gene
    5948
    UniGene
    655516
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    RBP2
    GeneCards
    RBP2