Cell Senescence Entries for RB1

Cell Types
Osteoblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Promotes
Observations
RB1 expression was knocked down in primary osteoblasts. These were then exposed to ionising radiation. Survival was enhanced in cells where RB1 had been knocked down due to the attenuated induction of senescence. Control cells showed increased SA-beta-galactosidase activity and changes in morphology when compared to cells where RB1 had been inhibited, demonstrating a role for RB1 in stress induced senescence.
Primary Reference

    RB1 Gene Information

    HGNC symbol
    RB1 
    Aliases
    RB; pRb; OSRC; pp110; p105-Rb; PPP1R130 
    Common name
    RB transcriptional corepressor 1 
    Entrez Id
    5925
    Description
    The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]

    RB1 Ontologies

    Gene Ontology
    Process: GO:82; G1/S transition of mitotic cell cycle
    GO:7265; Ras protein signal transduction
    GO:30521; androgen receptor signaling pathway
    GO:7050; cell cycle arrest
    GO:75; cell cycle checkpoint
    GO:51301; cell division
    GO:48667; cell morphogenesis involved in neuron differentiation
    GO:71466; cellular response to xenobiotic stimulus
    GO:6338; chromatin remodeling
    GO:16569; covalent chromatin modification
    GO:48565; digestive tract development
    And 38 more GO terms
    Cellular component: GO:16605; PML body
    GO:35189; Rb-E2F complex
    GO:16514; SWI/SNF complex
    GO:785; chromatin
    GO:8024; cyclin/CDK positive transcription elongation factor complex
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5819; spindle
    Function: GO:3677; DNA binding
    GO:1102; RNA polymerase II activating transcription factor binding
    GO:50681; androgen receptor binding
    GO:1047; core promoter binding
    GO:97718; disordered domain specific binding
    GO:42802; identical protein binding
    GO:61676; importin-alpha family protein binding
    GO:19900; kinase binding
    GO:3674; molecular_function
    GO:51219; phosphoprotein binding
    GO:5515; protein binding
    And 5 more GO terms
    Show all GO terms

    Homologs of RB1 in Model Organisms

    Danio rerio
    rb1
    Mus musculus
    Rb1
    Rattus norvegicus
    Rb1

    In other databases

    GenAge human genes
    • This gene is present as RB1

    External links

    OMIM
    614041
    Ensembl
    ENSG00000139687
    Entrez Gene
    5925
    UniGene
    408528
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    RB1
    GeneCards
    RB1