Cell Senescence Entries for RAF1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Promotes
Observations
Activation of RAF1 in normal human lung fibroblasts lead to an irreversible arrest of cellular proliferation and the premature onset of senescence, including induction of p21 and p16, morphological changes specific to senescence and increased SA-beta-galactosidase activity.
Primary Reference

    RAF1 Gene Information

    HGNC symbol
    RAF1 
    Aliases
    NS5; CRAF; Raf-1; c-Raf; CMD1NN 
    Common name
    Raf-1 proto-oncogene, serine/threonine kinase 
    Entrez Id
    5894
    Description
    This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2. [provided by RefSeq, Jul 2008]

    RAF1 Ontologies

    Gene Ontology
    Process: GO:165; MAPK cascade
    GO:186; activation of MAPKK activity
    GO:7190; activation of adenylate cyclase activity
    GO:6915; apoptotic process
    GO:30154; cell differentiation
    GO:8283; cell proliferation
    GO:71550; death-inducing signaling complex assembly
    GO:60324; face development
    GO:7507; heart development
    GO:35773; insulin secretion involved in cellular response to glucose stimulus
    GO:45104; intermediate filament cytoskeleton organization
    And 27 more GO terms
    Cellular component: GO:5794; Golgi apparatus
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5741; mitochondrial outer membrane
    GO:16607; nuclear speck
    GO:5886; plasma membrane
    GO:31143; pseudopodium
    Function: GO:5524; ATP binding
    GO:4709; MAP kinase kinase kinase activity
    GO:19899; enzyme binding
    GO:42802; identical protein binding
    GO:16301; kinase activity
    GO:46872; metal ion binding
    GO:31434; mitogen-activated protein kinase kinase binding
    GO:5515; protein binding
    GO:46982; protein heterodimerization activity
    GO:4672; protein kinase activity
    GO:4674; protein serine/threonine kinase activity
    And 2 more GO terms
    Show all GO terms

    Homologs of RAF1 in Model Organisms

    Danio rerio
    raf1b
    Mus musculus
    Raf1
    Rattus norvegicus
    Raf1

    In other databases

    LongevityMap
    • This gene is present as RAF1

    External links

    OMIM
    164760
    Ensembl
    ENSG00000132155
    Entrez Gene
    5894
    UniGene
    159130
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    RAF1
    GeneCards
    RAF1