Cell Senescence Entries for PTRF

Cell Types
Lung fibroblast, Cervical cancer
Cell Lines
WI-38, IMR-90, HeLa
Cancer Cell?
No
Method
Overexpression, Knockdown
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Overexpression of PTRF induced characteristic features of cellular senescence, whereas reduced PTRF expression extended the cellular replicative lifespan.
Primary Reference

    PTRF Gene Information

    HGNC symbol
    PTRF 
    Aliases
    CGL4; PTRF; CAVIN; FKSG13; cavin-1 
    Common name
    caveolae associated protein 1 
    Entrez Id
    284119
    Description
    This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy. [provided by RefSeq, Nov 2009]

    CAVIN1 Ontologies

    Gene Ontology
    Process: GO:6355; regulation of transcription, DNA-templated
    GO:6363; termination of RNA polymerase I transcription
    GO:6361; transcription initiation from RNA polymerase I promoter
    Cellular component: GO:5901; caveola
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5783; endoplasmic reticulum
    GO:43231; intracellular membrane-bounded organelle
    GO:45121; membrane raft
    GO:5739; mitochondrion
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5886; plasma membrane
    GO:43234; protein complex
    And 1 more GO terms
    Function: GO:3723; RNA binding
    GO:5515; protein binding
    GO:42134; rRNA primary transcript binding
    Show all GO terms

    Homologs of CAVIN1 in Model Organisms

    Danio rerio
    ptrfb
    Mus musculus
    Ptrf
    Rattus norvegicus
    Ptrf

    External links

    OMIM
    603198
    Ensembl
    ENSG00000177469
    Entrez Gene
    284119
    UniGene
    437191
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PTRF
    GeneCards
    PTRF