Cell Senescence Entries for PRPF19

Cell Types
Umbilical vein endothelial, Dermal fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Overexpression of SNEV (PRPF19) lead to a significant extension of cellular lifespan, delayed senescent cell morphology and decreased SA-beta-galactosidase activity.
Primary Reference

    PRPF19 Gene Information

    HGNC symbol
    PRPF19 
    Aliases
    PSO4; SNEV; PRP19; UBOX4; hPSO4; NMP200 
    Common name
    pre-mRNA processing factor 19 
    Entrez Id
    27339
    Description
    PSO4 is the human homolog of yeast Pso4, a gene essential for cell survival and DNA repair (Beck et al., 2008 [PubMed 18263876]).[supplied by OMIM, Sep 2008]

    PRPF19 Ontologies

    Gene Ontology
    Process: GO:34613; cellular protein localization
    GO:6303; double-strand break repair via nonhomologous end joining
    GO:349; generation of catalytic spliceosome for first transesterification step
    GO:1833; inner cell mass cell proliferation
    GO:8610; lipid biosynthetic process
    GO:398; mRNA splicing, via spliceosome
    GO:45665; negative regulation of neuron differentiation
    GO:48711; positive regulation of astrocyte differentiation
    GO:48026; positive regulation of mRNA splicing, via spliceosome
    GO:10498; proteasomal protein catabolic process
    GO:70534; protein K63-linked ubiquitination
    And 6 more GO terms
    Cellular component: GO:5662; DNA replication factor A complex
    GO:974; Prp19 complex
    GO:71006; U2-type catalytic step 1 spliceosome
    GO:71013; catalytic step 2 spliceosome
    GO:5737; cytoplasm
    GO:5811; lipid particle
    GO:16020; membrane
    GO:16607; nuclear speck
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:35861; site of double-strand break
    And 2 more GO terms
    Function: GO:42802; identical protein binding
    GO:5515; protein binding
    GO:61630; ubiquitin protein ligase activity
    GO:34450; ubiquitin-ubiquitin ligase activity
    Show all GO terms

    Homologs of PRPF19 in Model Organisms

    Caenorhabditis elegans
    T10F2.4
    Danio rerio
    prp19
    Drosophila melanogaster
    Prp19
    Mus musculus
    Prpf19
    Rattus norvegicus
    Prpf19
    Saccharomyces cerevisiae
    PRP19
    Schizosaccharomyces pombe
    cwf8

    External links

    OMIM
    608330
    Ensembl
    ENSG00000110107
    Entrez Gene
    27339
    UniGene
    502705
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PRPF19
    GeneCards
    PRPF19