Cell Senescence Entries for PROX1

Cell Types
Liver cancer
Cell Lines
HepG2, Hep3B, Mahlavu, SK-HEP1
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
It was demonstrated that PROX1 induced a senescence-like phenotype in liver cancer cells and resulted in reduced cell proliferation. p53 was found to be a key mediator of PROX1-induced growth suppression because Prox1 only induced senescence-like phenotype in HCC cells harboring wild type p53. In addition, knockdown of p53 by shRNA reversed the effect of PROX1.
Primary Reference

    PROX1 Gene Information

    HGNC symbol
    PROX1 
    Aliases
     
    Common name
    prospero homeobox 1 
    Entrez Id
    5629
    Description
    The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

    PROX1 Ontologies

    Gene Ontology
    Process: GO:90425; acinar cell differentiation
    GO:60414; aorta smooth muscle tissue morphogenesis
    GO:55009; atrial cardiac muscle tissue morphogenesis
    GO:7420; brain development
    GO:61114; branching involved in pancreas morphogenesis
    GO:55007; cardiac muscle cell differentiation
    GO:1709; cell fate determination
    GO:21707; cerebellar granule cell differentiation
    GO:7623; circadian rhythm
    GO:21542; dentate gyrus development
    GO:21516; dorsal spinal cord development
    And 49 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5634; nucleus
    Function: GO:50692; DBD domain binding
    GO:3677; DNA binding
    GO:50693; LBD domain binding
    GO:1046; core promoter sequence-specific DNA binding
    GO:16922; ligand-dependent nuclear receptor binding
    GO:5515; protein binding
    GO:3714; transcription corepressor activity
    GO:3705; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
    GO:3700; transcription factor activity, sequence-specific DNA binding
    GO:44212; transcription regulatory region DNA binding
    GO:1078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
    And 1 more GO terms
    Show all GO terms

    Homologs of PROX1 in Model Organisms

    Danio rerio
    prox1a
    Mus musculus
    Prox1
    Rattus norvegicus
    Prox1

    External links

    OMIM
    601546
    Ensembl
    ENSG00000117707
    Entrez Gene
    5629
    UniGene
    741808
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PROX1
    GeneCards
    PROX1