Cell Senescence Entries for PRMT6
- Cell Types
- Breast cancer, Breast epithelial
- Cell Lines
- MCF-10A, MCF-7, MDA-MB-231, MDA-MB-468, SK-BR-3
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Replicative
- Senescence Effect
- Inhibits
- Observations
- Knockdown of PRMT6 resulted in p21 derepression in breast cancer cells leading to cell cycle arrest, cellular senescence and reduced growth in soft agar assays (and in severe combined immuno-deficiency mice) for all the cancer lines examined.
- Primary Reference
PRMT6 Gene Information
- HGNC symbol
- PRMT6
- Aliases
- HRMT1L6
- Common name
- protein arginine methyltransferase 6
- Entrez Id
- 55170
- Description
- The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]
PRMT6 Ontologies
- Gene Ontology
-
Process: GO:6284; base-excision repair
GO:16049; cell growth
GO:90398; cellular senescence
GO:34970; histone H3-R2 methylation
GO:43985; histone H4-R3 methylation
GO:16571; histone methylation
GO:122; negative regulation of transcription from RNA polymerase II promoter
GO:45892; negative regulation of transcription, DNA-templated
GO:19919; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
GO:6351; transcription, DNA-templated
GO:16032; viral process
And 1 more GO terms Cellular component: GO:5730; nucleolus
GO:5654; nucleoplasm
GO:5634; nucleus
Function: GO:3682; chromatin binding
GO:42393; histone binding
GO:42054; histone methyltransferase activity
GO:70612; histone methyltransferase activity (H2A-R3 specific)
GO:70611; histone methyltransferase activity (H3-R2 specific)
GO:44020; histone methyltransferase activity (H4-R3 specific)
GO:8469; histone-arginine N-methyltransferase activity
GO:5515; protein binding
GO:16274; protein-arginine N-methyltransferase activity
GO:35242; protein-arginine omega-N asymmetric methyltransferase activity
GO:35241; protein-arginine omega-N monomethyltransferase activity
And 1 more GO terms
Homologs of PRMT6 in Model Organisms
- Danio rerio
- prmt6
- Mus musculus
- Prmt6
- Rattus norvegicus
- LOC100911617
External links
- OMIM
- 608274
- Ensembl
- ENSG00000198890
- Entrez Gene
- 55170
- UniGene
- 26006
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- PRMT6
- GeneCards
- PRMT6