Cell Senescence Entries for PRMT6

Cell Types
Breast cancer, Breast epithelial
Cell Lines
MCF-10A, MCF-7, MDA-MB-231, MDA-MB-468, SK-BR-3
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Knockdown of PRMT6 resulted in p21 derepression in breast cancer cells leading to cell cycle arrest, cellular senescence and reduced growth in soft agar assays (and in severe combined immuno-deficiency mice) for all the cancer lines examined.
Primary Reference

    PRMT6 Gene Information

    HGNC symbol
    PRMT6 
    Aliases
    HRMT1L6 
    Common name
    protein arginine methyltransferase 6 
    Entrez Id
    55170
    Description
    The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]

    PRMT6 Ontologies

    Gene Ontology
    Process: GO:6284; base-excision repair
    GO:16049; cell growth
    GO:90398; cellular senescence
    GO:34970; histone H3-R2 methylation
    GO:43985; histone H4-R3 methylation
    GO:16571; histone methylation
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    GO:45892; negative regulation of transcription, DNA-templated
    GO:19919; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
    GO:6351; transcription, DNA-templated
    GO:16032; viral process
    And 1 more GO terms
    Cellular component: GO:5730; nucleolus
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:3682; chromatin binding
    GO:42393; histone binding
    GO:42054; histone methyltransferase activity
    GO:70612; histone methyltransferase activity (H2A-R3 specific)
    GO:70611; histone methyltransferase activity (H3-R2 specific)
    GO:44020; histone methyltransferase activity (H4-R3 specific)
    GO:8469; histone-arginine N-methyltransferase activity
    GO:5515; protein binding
    GO:16274; protein-arginine N-methyltransferase activity
    GO:35242; protein-arginine omega-N asymmetric methyltransferase activity
    GO:35241; protein-arginine omega-N monomethyltransferase activity
    And 1 more GO terms
    Show all GO terms

    Homologs of PRMT6 in Model Organisms

    Danio rerio
    prmt6
    Mus musculus
    Prmt6
    Rattus norvegicus
    LOC100911617

    External links

    OMIM
    608274
    Ensembl
    ENSG00000198890
    Entrez Gene
    55170
    UniGene
    26006
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PRMT6
    GeneCards
    PRMT6