Cell Senescence Entries for PRMT6

Cell Types
Breast cancer, Breast epithelial
Cell Lines
MCF-10A, MCF-7, MDA-MB-231, MDA-MB-468, SK-BR-3
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Phalke et al. (2013) p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6. Nucleic Acids Res 40(19)9534-42 (PubMed)

PRMT6 Gene Information

HGNC symbol
PRMT6 
Aliases
FLJ10559; HRMT1L6 
Common name
protein arginine methyltransferase 6 
Entrez Id
55170
Description
The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011].

PRMT6 Ontologies

Gene Ontology
Process: GO:32259; methylation
GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:18216; peptidyl-arginine methylation
GO:43985; histone H4-R3 methylation
GO:16571; histone methylation
GO:6284; base-excision repair
GO:10821; regulation of mitochondrion organization
GO:31064; negative regulation of histone deacetylation
And 9 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5730; nucleolus
Function: GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:5515; protein binding
GO:16274; protein-arginine N-methyltransferase activity
GO:35241; protein-arginine omega-N monomethyltransferase activity
GO:44020; histone methyltransferase activity (H4-R3 specific)
GO:42054; histone methyltransferase activity
GO:35242; protein-arginine omega-N asymmetric methyltransferase activity
GO:42393; histone binding
GO:8469; histone-arginine N-methyltransferase activity
GO:3682; chromatin binding
And 5 more GO terms
Show all GO terms

Homologs of PRMT6 in Model Organisms

Danio rerio
prmt6
Mus musculus
Prmt6
Rattus norvegicus
LOC108348173
Rattus norvegicus
Prmt6
Rattus norvegicus
LOC108348173
Rattus norvegicus
Prmt6
Saccharomyces cerevisiae
HMT1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as HMT1
CellAge gene expression
  • This gene is present as PRMT6

External links

OMIM
608274
Ensembl
ENSG00000198890
Entrez Gene
55170
UniGene
26006
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PRMT6
GeneCards
PRMT6