Cell Senescence Entries for PRKCH

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Overexpression, Knockdown
Type of senescence
Stress-induced
Senescence Effect
Promotes
Observations
It was shown that PKC-eta (PRKCH), an epithelial specific and anti-apoptotic kinase, promoted senescence induced by oxidative stress and DNA damage. In PKC-eta known down cells SA-beta-galactosidase activity was significantly lower compared to control cells in response to oxidative stress. In cells overexpressing PKC-eta senescence was promoted due to upregulation of cell cycle inhibitors p21 and p27 and enhanced transcription and secretion of IL-6. PKC-eta was further shown to create a positive loop for reinforcing senescence by increasing the transcription of both IL-6 and IL-6 receptor, whereas the expression of IL-8 was specifically suppressed by PKC-eta.
Primary Reference

    PRKCH Gene Information

    HGNC symbol
    PRKCH 
    Aliases
    PKCL; PKC-L; PRKCL; nPKC-eta 
    Common name
    protein kinase C eta 
    Entrez Id
    5583
    Description
    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015]

    PRKCH Ontologies

    Gene Ontology
    Process: GO:35556; intracellular signal transduction
    GO:34351; negative regulation of glial cell apoptotic process
    GO:18105; peptidyl-serine phosphorylation
    GO:30168; platelet activation
    GO:50861; positive regulation of B cell receptor signaling pathway
    GO:51092; positive regulation of NF-kappaB transcription factor activity
    GO:60252; positive regulation of glial cell proliferation
    GO:45618; positive regulation of keratinocyte differentiation
    GO:10744; positive regulation of macrophage derived foam cell differentiation
    GO:1903078; positive regulation of protein localization to plasma membrane
    GO:70528; protein kinase C signaling
    And 4 more GO terms
    Cellular component: GO:5911; cell-cell junction
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:5886; plasma membrane
    Function: GO:5524; ATP binding
    GO:17160; Ral GTPase binding
    GO:4699; calcium-independent protein kinase C activity
    GO:19899; enzyme binding
    GO:46872; metal ion binding
    GO:4697; protein kinase C activity
    Show all GO terms

    Homologs of PRKCH in Model Organisms

    Caenorhabditis elegans
    pkc-1
    Danio rerio
    prkcha
    Drosophila melanogaster
    Pkc98E
    Mus musculus
    Prkch
    Rattus norvegicus
    Prkch

    External links

    OMIM
    605437
    Ensembl
    ENSG00000027075
    Entrez Gene
    5583
    UniGene
    333907
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PRKCH
    GeneCards
    PRKCH