Cell Senescence Entries for PRKCD

Cell Types
Lung fibroblast
Cell Lines
TIG-1
Cancer Cell?
No
Method
Overexpression, Knockdown
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Adenoviral transduction of PKC-delta (PRKCD) induced growth inhibition in lung fibroblasts (TIG-1 cells), causing enlarged and flattened cell morphology and increased SA-beta-galactosidase activity. Contrastly, RNA interference of PKC-delta antagonized oncogenic ras induced premature senescence.
Primary Reference

    PRKCD Gene Information

    HGNC symbol
    PRKCD 
    Aliases
    MAY1; PKCD; ALPS3; CVID9; nPKC-delta 
    Common name
    protein kinase C delta 
    Entrez Id
    5580
    Description
    Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

    PRKCD Ontologies

    Gene Ontology
    Process: GO:42100; B cell proliferation
    GO:38096; Fc-gamma receptor signaling pathway involved in phagocytosis
    GO:7202; activation of phospholipase C activity
    GO:32147; activation of protein kinase activity
    GO:6915; apoptotic process
    GO:60326; cell chemotaxis
    GO:7049; cell cycle
    GO:1904385; cellular response to angiotensin
    GO:70301; cellular response to hydrogen peroxide
    GO:71447; cellular response to hydroperoxide
    GO:90398; cellular senescence
    And 42 more GO terms
    Cellular component: GO:35578; azurophil granule lumen
    GO:5911; cell-cell junction
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5783; endoplasmic reticulum
    GO:70062; extracellular exosome
    GO:5576; extracellular region
    GO:16363; nuclear matrix
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:48471; perinuclear region of cytoplasm
    And 2 more GO terms
    Function: GO:5524; ATP binding
    GO:4699; calcium-independent protein kinase C activity
    GO:8047; enzyme activator activity
    GO:19899; enzyme binding
    GO:43560; insulin receptor substrate binding
    GO:19900; kinase binding
    GO:46872; metal ion binding
    GO:4715; non-membrane spanning protein tyrosine kinase activity
    GO:5515; protein binding
    GO:4697; protein kinase C activity
    GO:4672; protein kinase activity
    And 3 more GO terms
    Show all GO terms

    Homologs of PRKCD in Model Organisms

    Danio rerio
    BX005175.1
    Mus musculus
    Prkcd
    Rattus norvegicus
    Prkcd
    Schizosaccharomyces pombe
    pck1

    In other databases

    GenAge human genes
    • This gene is present as PRKCD

    External links

    OMIM
    176977
    Ensembl
    ENSG00000163932
    Entrez Gene
    5580
    UniGene
    155342
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PRKCD
    GeneCards
    PRKCD