Cell Senescence Entries for PPM1D

Cell Types
Mesenchymal stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Expression of the WIP1 protein (encoded by the PPM1D gene) significantly lowered the expression of p16 and lead to p38 MAPK inactivation, ultimately leading to a delayed cellular senescence of human mesenchymal stem cells (MSCs), including extended replicative potential and normal morphology, in addition to longer maintenance of cell multilineage differentiation potential.
Primary Reference

    PPM1D Gene Information

    HGNC symbol
    PPM1D 
    Aliases
    WIP1; PP2C-DELTA 
    Common name
    protein phosphatase, Mg2+/Mn2+ dependent 1D 
    Entrez Id
    8493
    Description
    The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. [provided by RefSeq, Jul 2008]

    PPM1D Ontologies

    Gene Ontology
    Process: GO:86; G2/M transition of mitotic cell cycle
    GO:9267; cellular response to starvation
    GO:8285; negative regulation of cell proliferation
    GO:35970; peptidyl-threonine dephosphorylation
    GO:6470; protein dephosphorylation
    GO:9617; response to bacterium
    GO:9314; response to radiation
    Cellular component: GO:5634; nucleus
    Function: GO:46872; metal ion binding
    GO:51019; mitogen-activated protein kinase binding
    GO:5515; protein binding
    GO:4722; protein serine/threonine phosphatase activity
    Show all GO terms

    Homologs of PPM1D in Model Organisms

    Danio rerio
    ppm1db
    Mus musculus
    Ppm1d
    Rattus norvegicus
    Ppm1d

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Ppm1d
    GenAge human genes
    • This gene is present as PPM1D

    External links

    OMIM
    605100
    Ensembl
    ENSG00000170836
    Entrez Gene
    8493
    UniGene
    286073
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PPM1D
    GeneCards
    PPM1D