Cell Senescence Entries for POT1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
RNA interference of POT1 lead to the loss of telomeric single-stranded overhangs and induced apoptosis, chromosomal instability, and senescence in cells.
Primary Reference

    POT1 Gene Information

    HGNC symbol
    POT1 
    Aliases
    GLM9; CMM10; HPOT1 
    Common name
    protection of telomeres 1 
    Entrez Id
    25913
    Description
    This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]

    POT1 Ontologies

    Gene Ontology
    Process: GO:32508; DNA duplex unwinding
    GO:70200; establishment of protein localization to telomere
    GO:51974; negative regulation of telomerase activity
    GO:32211; negative regulation of telomere maintenance via telomerase
    GO:1905776; positive regulation of DNA helicase activity
    GO:60383; positive regulation of DNA strand elongation
    GO:51096; positive regulation of helicase activity
    GO:51973; positive regulation of telomerase activity
    GO:32212; positive regulation of telomere maintenance via telomerase
    GO:1905774; regulation of DNA helicase activity
    GO:32210; regulation of telomere maintenance via telomerase
    And 5 more GO terms
    Cellular component: GO:781; chromosome, telomeric region
    GO:784; nuclear chromosome, telomeric region
    GO:783; nuclear telomere cap complex
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:70187; shelterin complex
    Function: GO:17151; DEAD/H-box RNA helicase binding
    GO:1990955; G-rich single-stranded DNA binding
    GO:98505; G-rich strand telomeric DNA binding
    GO:32357; oxidized purine DNA binding
    GO:5515; protein binding
    GO:43047; single-stranded telomeric DNA binding
    GO:10521; telomerase inhibitor activity
    GO:61821; telomeric D-loop binding
    GO:42162; telomeric DNA binding
    GO:61849; telomeric G-quadruplex DNA binding
    Show all GO terms

    Homologs of POT1 in Model Organisms

    Danio rerio
    pot1
    Mus musculus
    Pot1
    Rattus norvegicus
    Pot1b
    Schizosaccharomyces pombe
    pot1

    In other databases

    LongevityMap
    • This gene is present as POT1

    External links

    OMIM
    606478
    Ensembl
    ENSG00000128513
    Entrez Gene
    25913
    UniGene
    31968
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    POT1
    GeneCards
    POT1