Cell Senescence Entries for PML

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Promotes
Observations
Overexpression of PML induced senescence in human lung fibroblasts, in a p53-dependent manner. PML-overexpressing fibroblasts had arrested proliferation, accumulating in the G1 phase with no BrdU incorporation. The cells demonstrated a senescence phenotype becoming flat and enlarged and displayed increased SA-beta-galactosidase activity.
Primary Reference

    PML Gene Information

    HGNC symbol
    PML 
    Aliases
    MYL; RNF71; PP8675; TRIM19 
    Common name
    promyelocytic leukemia 
    Entrez Id
    5371
    Description
    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

    PML Ontologies

    Gene Ontology
    Process: GO:6977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
    GO:30578; PML body organization
    GO:7184; SMAD protein import into nucleus
    GO:6919; activation of cysteine-type endopeptidase activity involved in apoptotic process
    GO:60444; branching involved in mammary gland duct morphogenesis
    GO:7050; cell cycle arrest
    GO:45165; cell fate commitment
    GO:71353; cellular response to interleukin-4
    GO:90398; cellular senescence
    GO:32922; circadian regulation of gene expression
    GO:7182; common-partner SMAD protein phosphorylation
    And 41 more GO terms
    Cellular component: GO:16605; PML body
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:31901; early endosome membrane
    GO:42406; extrinsic component of endoplasmic reticulum membrane
    GO:792; heterochromatin
    GO:784; nuclear chromosome, telomeric region
    GO:16363; nuclear matrix
    GO:31965; nuclear membrane
    GO:5730; nucleolus
    GO:5654; nucleoplasm
    And 2 more GO terms
    Function: GO:3677; DNA binding
    GO:46332; SMAD binding
    GO:32183; SUMO binding
    GO:5515; protein binding
    GO:42803; protein homodimerization activity
    GO:31625; ubiquitin protein ligase binding
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of PML in Model Organisms

    Mus musculus
    Pml
    Rattus norvegicus
    Pml

    In other databases

    GenAge human genes
    • This gene is present as PML

    External links

    OMIM
    102578
    Ensembl
    ENSG00000140464
    Entrez Gene
    5371
    UniGene
    526464
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PML
    GeneCards
    PML