Cell Senescence Entries for PIM1

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
2BS, BJ, WI-38
Cancer Cell?
No
Method
Overexpression, Knockdown
Type of senescence
Oncogene-induced, Replicative
Senescence Effect
Promotes
Observations
The expression of proto-oncogene PIM1 was induced at the transcriptional level during senescence. Ectopic expression of PIM1 resulted in premature senescence. Conversely, inhibition of PIM1 alleviated both replicative and oncogene-induced senescence. It was found that PIM1 interacted with, and phosphorylated, heterochromatin protein 1 gamma (HP1-gamma) on Ser93. This PIM1-mediated HP1-gamma phosphorylation, enhanced HP1-gamma's capacity to bind to H3K9me3, resulting in SA-heterochromatin foci formation and suppression of proliferative genes, such as CCNA2 and PCNA. Analysis of the mechanism underlying the up-regulation of PIM1 expression during senescence demonstrated that IL-6 was responsible for PIM1 induction.
Primary Reference

    PIM1 Gene Information

    HGNC symbol
    PIM1 
    Aliases
    PIM 
    Common name
    Pim-1 proto-oncogene, serine/threonine kinase 
    Entrez Id
    5292
    Description
    The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011]

    PIM1 Ontologies

    Gene Ontology
    Process: GO:6915; apoptotic process
    GO:7049; cell cycle
    GO:8283; cell proliferation
    GO:30212; hyaluronan metabolic process
    GO:7275; multicellular organism development
    GO:43066; negative regulation of apoptotic process
    GO:43433; negative regulation of sequence-specific DNA binding transcription factor activity
    GO:60045; positive regulation of cardiac muscle cell proliferation
    GO:1905062; positive regulation of cardioblast proliferation
    GO:46777; protein autophosphorylation
    GO:6468; protein phosphorylation
    And 3 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5730; nucleolus
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5886; plasma membrane
    Function: GO:5524; ATP binding
    GO:30145; manganese ion binding
    GO:5515; protein binding
    GO:4674; protein serine/threonine kinase activity
    GO:43024; ribosomal small subunit binding
    GO:8134; transcription factor binding
    Show all GO terms

    Homologs of PIM1 in Model Organisms

    Danio rerio
    pim1
    Mus musculus
    Pim1
    Rattus norvegicus
    Pim1

    External links

    OMIM
    164960
    Ensembl
    ENSG00000137193
    Entrez Gene
    5292
    UniGene
    81170
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PIM1
    GeneCards
    PIM1