Cell Senescence Entries for PEX19

Cell Types
Osteosarcoma
Cell Lines
U2OS
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Promotes
Observations
Overexpression of PEX19 made cells more sensitive to 5AZA-dC-induced senescence, induces a stronger growth arrest and enhanced induction of p16.
Primary Reference

    PEX19 Gene Information

    HGNC symbol
    PEX19 
    Aliases
    PXF; HK33; PMP1; PMPI; PXMP1; PBD12A; D1S2223E 
    Common name
    peroxisomal biogenesis factor 19 
    Entrez Id
    5824
    Description
    This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. These disorders have at least 14 complementation groups, with more than one phenotype being observed for some complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of Zellweger syndrome (ZWS), as well as peroxisome biogenesis disorder complementation group 14 (PBD-CG14), which is also known as PBD-CGJ. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

    PEX19 Ontologies

    Gene Ontology
    Process: GO:61077; chaperone-mediated protein folding
    GO:72321; chaperone-mediated protein transport
    GO:72663; establishment of protein localization to peroxisome
    GO:1900131; negative regulation of lipid binding
    GO:16559; peroxisome fission
    GO:7031; peroxisome organization
    GO:45046; protein import into peroxisome membrane
    GO:50821; protein stabilization
    GO:6625; protein targeting to peroxisome
    GO:55085; transmembrane transport
    Cellular component: GO:31526; brush border membrane
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5654; nucleoplasm
    GO:5778; peroxisomal membrane
    GO:5777; peroxisome
    GO:43234; protein complex
    Function: GO:51117; ATPase binding
    GO:36105; peroxisome membrane class-1 targeting sequence binding
    GO:47485; protein N-terminus binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of PEX19 in Model Organisms

    Caenorhabditis elegans
    prx-19
    Danio rerio
    pex19
    Drosophila melanogaster
    Pex19
    Mus musculus
    Pex19
    Rattus norvegicus
    LOC100911356

    External links

    OMIM
    600279
    Ensembl
    ENSG00000162735
    Entrez Gene
    5824
    UniGene
    517232
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PEX19
    GeneCards
    PEX19