Cell Senescence Entries for PEBP1

Cell Types
Prostate cancer, Colon cancer, Lung cancer, Gastric cancer
Cell Lines
A549, MKN45, PC-3, HCT116
Cancer Cell?
Yes
Method
Overexpression, Knockdown
Type of senescence
Stress-induced
Senescence Effect
Promotes
Observations
Overexpression of RKIP (PEBP1) induced cellular senescence in several types of cell lines, including p53-deficient cells, whereas the elimination of RKIP by siRNA or forced expression of ERK blocked p53-mediated cellular senescence.
Primary Reference

    PEBP1 Gene Information

    HGNC symbol
    PEBP1 
    Aliases
    PBP; HCNP; PEBP; RKIP; HCNPpp; PEBP-1; HEL-210; HEL-S-34; HEL-S-96 
    Common name
    phosphatidylethanolamine binding protein 1 
    Entrez Id
    5037
    Description
    This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]

    PEBP1 Ontologies

    Gene Ontology
    Process: GO:165; MAPK cascade
    GO:10951; negative regulation of endopeptidase activity
    Cellular component: GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:5634; nucleus
    Function: GO:5524; ATP binding
    GO:3723; RNA binding
    GO:19899; enzyme binding
    GO:8429; phosphatidylethanolamine binding
    GO:5515; protein binding
    GO:19901; protein kinase binding
    GO:4867; serine-type endopeptidase inhibitor activity
    Show all GO terms

    Homologs of PEBP1 in Model Organisms

    Caenorhabditis elegans
    F40A3.3
    Danio rerio
    pebp1
    Drosophila melanogaster
    CG17919
    Mus musculus
    Pebp1
    Rattus norvegicus
    Pbp2
    Saccharomyces cerevisiae
    TFS1

    External links

    OMIM
    604591
    Ensembl
    ENSG00000089220
    Entrez Gene
    5037
    UniGene
    433863
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PEBP1
    GeneCards
    PEBP1