Cell Senescence Entries for PDZD2

Cell Types
Breast cancer, Prostate cancer, Liver cancer
Cell Lines
DU145
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Expression of PDZD2 induced senescence of prostate cancer cells (DU145) and quiescence of breast cancer cells (MCF-7) and liver cancer cells (Hep-G2).
Primary Reference

    PDZD2 Gene Information

    HGNC symbol
    PDZD2 
    Aliases
    AIPC; PIN1; PAPIN; PDZK3 
    Common name
    PDZ domain containing 2 
    Entrez Id
    23037
    Description
    The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis. [provided by RefSeq, Dec 2015]

    PDZD2 Ontologies

    Gene Ontology
    Process: GO:7155; cell adhesion
    Cellular component: GO:5911; cell-cell junction
    GO:5737; cytoplasm
    GO:5783; endoplasmic reticulum
    GO:5576; extracellular region
    GO:5634; nucleus
    Function:
    Show all GO terms

    Homologs of PDZD2 in Model Organisms

    Danio rerio
    pdzd2
    Drosophila melanogaster
    CG15803
    Mus musculus
    Pdzd2
    Rattus norvegicus
    Pdzd2

    External links

    OMIM
    610697
    Ensembl
    ENSG00000133401
    Entrez Gene
    23037
    UniGene
    481819
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PDZD2
    GeneCards
    PDZD2