Cell Senescence Entries for PDPK1

Cell Types
Lung fibroblast, Embryonic kidney
Cell Lines
IMR-90, MRC-5, HEK293T
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    PDPK1 Gene Information

    HGNC symbol
    PDPK1 
    Aliases
    PDK1; PDPK2; PDPK2P; PRO0461 
    Common name
    3-phosphoinositide dependent protein kinase 1 
    Entrez Id
    5170
    Description

    PDPK1 Ontologies

    Gene Ontology
    Process: GO:38095; Fc-epsilon receptor signaling pathway
    GO:31295; T cell costimulation
    GO:50852; T cell receptor signaling pathway
    GO:30036; actin cytoskeleton organization
    GO:32148; activation of protein kinase B activity
    GO:19722; calcium-mediated signaling
    GO:16477; cell migration
    GO:1990416; cellular response to brain-derived neurotrophic factor stimulus
    GO:71364; cellular response to epidermal growth factor stimulus
    GO:32869; cellular response to insulin stimulus
    GO:7173; epidermal growth factor receptor signaling pathway
    And 26 more GO terms
    Cellular component: GO:42995; cell projection
    GO:5737; cytoplasm
    GO:31410; cytoplasmic vesicle
    GO:5829; cytosol
    GO:5925; focal adhesion
    GO:5622; intracellular
    GO:16020; membrane
    GO:5654; nucleoplasm
    GO:43204; perikaryon
    GO:5886; plasma membrane
    GO:14069; postsynaptic density
    And 1 more GO terms
    Function: GO:4676; 3-phosphoinositide-dependent protein kinase activity
    GO:5524; ATP binding
    GO:5158; insulin receptor binding
    GO:16301; kinase activity
    GO:16004; phospholipase activator activity
    GO:43274; phospholipase binding
    GO:5515; protein binding
    GO:19901; protein kinase binding
    GO:4674; protein serine/threonine kinase activity
    Show all GO terms

    Homologs of PDPK1 in Model Organisms

    Danio rerio
    pdpk1b
    Mus musculus
    Pdpk1
    Rattus norvegicus
    Pdpk1

    In other databases

    GenAge human genes
    • This gene is present as PDPK1
    LongevityMap
    • This gene is present as PDPK1

    External links

    OMIM
    605213
    Ensembl
    ENSG00000140992
    Entrez Gene
    5170
    UniGene
    459691
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PDPK1
    GeneCards
    PDPK1