Cell Senescence Entries for PDCD10

Cell Types
Coronary artery endothelial, Lung fibroblast
Cell Lines
Primary cell, IMR-90
Cancer Cell?
No
Method
Knockout
Type of senescence
Replicative, Oncogene-induced
Senescence Effect
Promotes
Observations
Loss of CCM3 (PDCD10) impaired the senescence response. CCM3 normally acts to induce the transcription factor C/EPB-beta, which normally implements the SASP. Induction of C/EBP-beta and cytokines was impaired in the absence of CCM3 in response to cytokines in nonsenescent cells, pointing to it being a primary defect and not secondary to impaired senescence. CCM3-deficient cells also had a defect in autophagy at late passages of culture and this defect was not dependent on impaired senescence, as it was evident in immortal cells after nutrient starvation. It was further postulated that these two defects may be related, as enforcing autophagy in CCM3-deficient late passage cells increases C/EBP-beta cytokine expression.
Primary Reference

    PDCD10 Gene Information

    HGNC symbol
    PDCD10 
    Aliases
    CCM3; TFAR15 
    Common name
    programmed cell death 10 
    Entrez Id
    11235
    Description
    This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

    PDCD10 Ontologies

    Gene Ontology
    Process: GO:90168; Golgi reassembly
    GO:1525; angiogenesis
    GO:51683; establishment of Golgi localization
    GO:36481; intrinsic apoptotic signaling pathway in response to hydrogen peroxide
    GO:43066; negative regulation of apoptotic process
    GO:1903588; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
    GO:90051; negative regulation of cell migration involved in sprouting angiogenesis
    GO:10629; negative regulation of gene expression
    GO:43406; positive regulation of MAP kinase activity
    GO:45747; positive regulation of Notch signaling pathway
    GO:30335; positive regulation of cell migration
    And 12 more GO terms
    Cellular component: GO:5794; Golgi apparatus
    GO:139; Golgi membrane
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:5886; plasma membrane
    Function: GO:47485; protein N-terminus binding
    GO:5515; protein binding
    GO:42803; protein homodimerization activity
    GO:19901; protein kinase binding
    Show all GO terms

    Homologs of PDCD10 in Model Organisms

    Caenorhabditis elegans
    C14A4.11
    Danio rerio
    pdcd10a
    Drosophila melanogaster
    CG5073
    Mus musculus
    Pdcd10
    Rattus norvegicus
    Pdcd10

    External links

    OMIM
    609118
    Ensembl
    ENSG00000114209
    Entrez Gene
    11235
    UniGene
    478150
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PDCD10
    GeneCards
    PDCD10