Cell Senescence Entries for PATZ1

Cell Types
Umbilical vein endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Knockdown of PATZ1 in young endothelial cells accelerated premature senescence, including growth arrest, increased p53 protein level and SA-beta-galactosidase activity and repressed endothelial cell tube formation. In contrast, overexpression of PATZ1 in senescent cells reversed senescent phenotypes.
Primary Reference

    PATZ1 Gene Information

    HGNC symbol
    PATZ1 
    Aliases
    ZSG; MAZR; PATZ; RIAZ; ZBTB19; ZNF278; dJ400N23 
    Common name
    POZ/BTB and AT hook containing zinc finger 1 
    Entrez Id
    23598
    Description
    The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]

    PATZ1 Ontologies

    Gene Ontology
    Process: GO:30217; T cell differentiation
    GO:8584; male gonad development
    GO:45892; negative regulation of transcription, DNA-templated
    GO:45944; positive regulation of transcription from RNA polymerase II promoter
    GO:6355; regulation of transcription, DNA-templated
    GO:7283; spermatogenesis
    GO:6366; transcription from RNA polymerase II promoter
    Cellular component: GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:3677; DNA binding
    GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
    GO:3682; chromatin binding
    GO:46872; metal ion binding
    GO:1077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
    Show all GO terms

    Homologs of PATZ1 in Model Organisms

    Danio rerio
    patz1
    Mus musculus
    Patz1
    Rattus norvegicus
    Patz1

    External links

    OMIM
    605165
    Ensembl
    ENSG00000100105
    Entrez Gene
    23598
    UniGene
    731398
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    PATZ1
    GeneCards
    PATZ1