Cell Senescence Entries for NR2E1

Cell Types
Prostate epithelial, Lung fibroblast, Neural Stem
Cell Lines
IMR-90, WI-38
Cancer Cell?
No
Method
Knockout
Type of senescence
Oncogene-induced
Senescence Effect
Unclear
Observations
NR2E1 knockdown human fibroblasts and epithelial cells showed restrained senescence. It was also shown that NR2E1 regulated CBX7 and restrained senescence in NSCs.
Primary Reference

    NR2E1 Gene Information

    HGNC symbol
    NR2E1 
    Aliases
    TLL; TLX; XTLL 
    Common name
    nuclear receptor subfamily 2 group E member 1 
    Entrez Id
    7101
    Description
    The protein encoded by this gene is an orphan receptor involved in retinal development. The encoded protein also regulates adult neural stem cell proliferation and may be involved in control of aggressive behavior. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

    NR2E1 Ontologies

    Gene Ontology
    Process: GO:2118; aggressive behavior
    GO:21764; amygdala development
    GO:21960; anterior commissure morphogenesis
    GO:1662; behavioral fear response
    GO:45165; cell fate commitment
    GO:21895; cerebral cortex neuron differentiation
    GO:21542; dentate gyrus development
    GO:30198; extracellular matrix organization
    GO:21872; forebrain generation of neurons
    GO:21819; layer formation in cerebral cortex
    GO:60291; long-term synaptic potentiation
    And 22 more GO terms
    Cellular component: GO:5654; nucleoplasm
    Function: GO:42826; histone deacetylase binding
    GO:43565; sequence-specific DNA binding
    GO:3707; steroid hormone receptor activity
    GO:1077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
    GO:1078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of NR2E1 in Model Organisms

    Danio rerio
    nr2e1
    Drosophila melanogaster
    dsf
    Mus musculus
    Nr2e1
    Rattus norvegicus
    Nr2e1

    External links

    OMIM
    603849
    Ensembl
    ENSG00000112333
    Entrez Gene
    7101
    UniGene
    157688
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    NR2E1
    GeneCards
    NR2E1