Cell Senescence Entries for NOTCH3

Cell Types
Glioma, Fibroblast, Melanoma, Foreskin fibroblast, Breast cancer
Cell Lines
BJ, LF1, WS1, MDA-MB-231, A375P, T98G
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Promotes
Observations
NOTCH3 expression was elevated upon various senescence-inducing stimuli. This upregulation of Notch3 was required for the induction of p21 expression in senescent cells. Downregulation of Notch3 led to delayed onset of senescence and extended replicative lifespan, whereas expression of Notch3 was sufficient to activate senescence and p21 expression.
Primary Reference

    NOTCH3 Gene Information

    HGNC symbol
    NOTCH3 
    Aliases
    IMF2; LMNS; CASIL; CADASIL; CADASIL1 
    Common name
    notch 3 
    Entrez Id
    4854
    Description
    This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008]

    NOTCH3 Ontologies

    Gene Ontology
    Process: GO:7220; Notch receptor processing
    GO:7219; Notch signaling pathway
    GO:48844; artery morphogenesis
    GO:30900; forebrain development
    GO:72104; glomerular capillary formation
    GO:45665; negative regulation of neuron differentiation
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    GO:48663; neuron fate commitment
    GO:48661; positive regulation of smooth muscle cell proliferation
    GO:45944; positive regulation of transcription from RNA polymerase II promoter
    GO:6367; transcription initiation from RNA polymerase II promoter
    And 1 more GO terms
    Cellular component: GO:139; Golgi membrane
    GO:15629; actin cytoskeleton
    GO:5829; cytosol
    GO:5789; endoplasmic reticulum membrane
    GO:5576; extracellular region
    GO:16021; integral component of membrane
    GO:5654; nucleoplasm
    GO:5886; plasma membrane
    GO:43235; receptor complex
    Function: GO:45296; cadherin binding
    GO:5509; calcium ion binding
    GO:19899; enzyme binding
    GO:5515; protein binding
    GO:4872; receptor activity
    Show all GO terms

    Homologs of NOTCH3 in Model Organisms

    Mus musculus
    Notch3
    Rattus norvegicus
    Notch3

    External links

    OMIM
    600276
    Ensembl
    ENSG00000074181
    Entrez Gene
    4854
    UniGene
    8546
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    NOTCH3
    GeneCards
    NOTCH3