Cell Senescence Entries for NFE2L2

Cell Types
Lung fibroblast
Cell Lines
HFL-1
Cancer Cell?
No
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Knockdown of NRF2 (NFE2L2) resulted in inhibition of proliferation and induction of premature senescence in HFL-1 fibroblasts, accompanied by typical senescent morphology, increased SA-beta-galactosidase activity and increased levels of p16.
Primary Reference

    NFE2L2 Gene Information

    HGNC symbol
    NFE2L2 
    Aliases
    NRF2; HEBP1 
    Common name
    nuclear factor, erythroid 2 like 2 
    Entrez Id
    4780
    Description
    This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]

    NFE2L2 Ontologies

    Gene Ontology
    Process: GO:36499; PERK-mediated unfolded protein response
    GO:7568; aging
    GO:45454; cell redox homeostasis
    GO:35690; cellular response to drug
    GO:71498; cellular response to fluid shear stress
    GO:42149; cellular response to glucose starvation
    GO:70301; cellular response to hydrogen peroxide
    GO:71456; cellular response to hypoxia
    GO:71499; cellular response to laminar fluid shear stress
    GO:34599; cellular response to oxidative stress
    GO:71356; cellular response to tumor necrosis factor
    And 27 more GO terms
    Cellular component: GO:5794; Golgi apparatus
    GO:5813; centrosome
    GO:785; chromatin
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:5886; plasma membrane
    GO:32993; protein-DNA complex
    Function: GO:3677; DNA binding
    GO:1102; RNA polymerase II activating transcription factor binding
    GO:980; RNA polymerase II distal enhancer sequence-specific DNA binding
    GO:5515; protein binding
    GO:19904; protein domain specific binding
    GO:1221; transcription cofactor binding
    GO:3700; transcription factor activity, sequence-specific DNA binding
    GO:44212; transcription regulatory region DNA binding
    GO:976; transcription regulatory region sequence-specific DNA binding
    GO:1205; transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding
    Show all GO terms

    Homologs of NFE2L2 in Model Organisms

    Danio rerio
    nfe2l2a
    Mus musculus
    Nfe2l2
    Rattus norvegicus
    Nfe2l2

    In other databases

    GenAge human genes
    • This gene is present as NFE2L2

    External links

    OMIM
    600492
    Ensembl
    ENSG00000116044
    Entrez Gene
    4780
    UniGene
    744006
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    NFE2L2
    GeneCards
    NFE2L2