Cell Senescence Entries for NDRG1

Cell Types
Liver cancer
Cell Lines
HepG2, Hep3B, Huh7, PLC/PRF/5
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
NDRG1 significantly impaired liver cancer cell growth by inducing extensive cellular senescence of liver cancer cells both in vitro and in vivo, accompanied by cell cycle arrest at the G1 phase. The observed antitumor effects of NDRG1 suppression were correlated with activation of major senescence-associated signalling pathways, such as upregulation of tumor suppressors p53, p21 and p16, and decreased phosphorylation of Rb1.
Primary Reference

    NDRG1 Gene Information

    HGNC symbol
    NDRG1 
    Aliases
    GC4; RTP; DRG1; NDR1; NMSL; TDD5; CAP43; CMT4D; DRG-1; HMSNL; RIT42; TARG1; PROXY1 
    Common name
    N-myc downstream regulated 1 
    Entrez Id
    10397
    Description
    This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

    NDRG1 Ontologies

    Gene Ontology
    Process: GO:30330; DNA damage response, signal transduction by p53 class mediator
    GO:71456; cellular response to hypoxia
    GO:45576; mast cell activation
    GO:8285; negative regulation of cell proliferation
    GO:32287; peripheral nervous system myelin maintenance
    GO:90232; positive regulation of spindle checkpoint
    GO:42981; regulation of apoptotic process
    GO:10038; response to metal ion
    Cellular component: GO:5913; cell-cell adherens junction
    GO:5813; centrosome
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:5874; microtubule
    GO:15630; microtubule cytoskeleton
    GO:43209; myelin sheath
    GO:5634; nucleus
    GO:48471; perinuclear region of cytoplasm
    GO:5886; plasma membrane
    And 2 more GO terms
    Function: GO:17137; Rab GTPase binding
    GO:45296; cadherin binding
    GO:43015; gamma-tubulin binding
    GO:8017; microtubule binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of NDRG1 in Model Organisms

    Danio rerio
    ndrg1a
    Mus musculus
    Ndrg1
    Rattus norvegicus
    Ndrg1

    In other databases

    GenAge microarray genes
    • This gene is present as NDRG1

    External links

    OMIM
    605262
    Ensembl
    ENSG00000104419
    Entrez Gene
    10397
    UniGene
    372914
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    NDRG1
    GeneCards
    NDRG1