Cell Senescence Entries for NANOG

Cell Types
Fibroblast, Dermal fibroblast
Cell Lines
NIH3T3, Oct4-GiP
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
NANOG enhanced the proliferation of both NIH 3T3 and primary fibroblast cells. NANOG transduction into primary fibroblasts resulted in decreased SA-beta-galactosidase activity. Investigation of cell cycle factors revealed that transient activation of NANOG correlated with consistent downregulation of the cell cycle inhibitor p27, a common marker of senescence.
Primary Reference

    NANOG Gene Information

    HGNC symbol
    NANOG 
    Aliases
     
    Common name
    Nanog homeobox 
    Entrez Id
    79923
    Description
    The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

    NANOG Ontologies

    Gene Ontology
    Process: GO:30154; cell differentiation
    GO:8283; cell proliferation
    GO:1714; endodermal cell fate specification
    GO:1903507; negative regulation of nucleic acid-templated transcription
    GO:45944; positive regulation of transcription from RNA polymerase II promoter
    GO:45595; regulation of cell differentiation
    GO:10468; regulation of gene expression
    GO:6355; regulation of transcription, DNA-templated
    GO:35019; somatic stem cell population maintenance
    GO:19827; stem cell population maintenance
    GO:6351; transcription, DNA-templated
    And 1 more GO terms
    Cellular component: GO:5730; nucleolus
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:3677; DNA binding
    GO:5515; protein binding
    GO:43565; sequence-specific DNA binding
    GO:3714; transcription corepressor activity
    GO:3700; transcription factor activity, sequence-specific DNA binding
    Show all GO terms

    Homologs of NANOG in Model Organisms

    No homologs found

    External links

    OMIM
    607937
    Ensembl
    ENSG00000111704
    Entrez Gene
    79923
    UniGene
    635882
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    NANOG
    GeneCards
    NANOG