Cell Senescence Entries for Mar-05

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Knockdown of MARCH5 resulted in increased cellular senescence, marked by flattened cells with an enlarged cellular morphology, elongated mitochondria and increased SA-beta-galactosidase activity.
Primary Reference

    Mar-05 Gene Information

    HGNC symbol
    Mar-05 
    Aliases
    MITOL; RNF153; MARCH-V 
    Common name
    membrane associated ring-CH-type finger 5 
    Entrez Id
    54708
    Description
    MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008]

    MARCH5 Ontologies

    Gene Ontology
    Process: GO:90344; negative regulation of cell aging
    GO:90141; positive regulation of mitochondrial fission
    GO:51865; protein autoubiquitination
    GO:70585; protein localization to mitochondrion
    GO:209; protein polyubiquitination
    GO:90140; regulation of mitochondrial fission
    Cellular component: GO:5783; endoplasmic reticulum
    GO:5789; endoplasmic reticulum membrane
    GO:16021; integral component of membrane
    GO:16020; membrane
    GO:5741; mitochondrial outer membrane
    GO:5739; mitochondrion
    Function: GO:51020; GTPase binding
    GO:5515; protein binding
    GO:4842; ubiquitin-protein transferase activity
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of MARCH5 in Model Organisms

    Danio rerio
    march5
    Drosophila melanogaster
    CG9855
    Mus musculus
    March5
    Rattus norvegicus
    March5

    External links

    OMIM
    610637
    Ensembl
    ENSG00000198060
    Entrez Gene
    54708
    UniGene
    573490
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    Mar-05
    GeneCards
    Mar-05