Cell Senescence Entries for MYC

Cell Types
Fibroblast
Cell Lines
LF1
Cancer Cell?
No
Method
Knockout
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Observations
Knockdown of c-Myc (MYC) signalling in human diploid fibroblats (HDFs) was found to trigger telomere-independent senescence. This process was mediated by cyclin-dependent kinase inhibitor p16, a common marker of senescence.
Primary Reference

    MYC Gene Information

    HGNC symbol
    MYC 
    Aliases
    MRTL; MYCC; c-Myc; bHLHe39 
    Common name
    MYC proto-oncogene, bHLH transcription factor 
    Entrez Id
    4609
    Description
    The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. [provided by RefSeq, Jul 2008]

    MYC Ontologies

    Gene Ontology
    Process: GO:70371; ERK1 and ERK2 cascade
    GO:82; G1/S transition of mitotic cell cycle
    GO:165; MAPK cascade
    GO:7219; Notch signaling pathway
    GO:1904837; beta-catenin-TCF complex assembly
    GO:1658; branching involved in ureteric bud morphogenesis
    GO:60070; canonical Wnt signaling pathway
    GO:7050; cell cycle arrest
    GO:6879; cellular iron ion homeostasis
    GO:6974; cellular response to DNA damage stimulus
    GO:34644; cellular response to UV
    And 35 more GO terms
    Cellular component: GO:5829; cytosol
    GO:5730; nucleolus
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:43234; protein complex
    Function: GO:3677; DNA binding
    GO:70888; E-box binding
    GO:978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
    GO:33613; activating transcription factor binding
    GO:5515; protein binding
    GO:32403; protein complex binding
    GO:46983; protein dimerization activity
    GO:70491; repressing transcription factor binding
    GO:3700; transcription factor activity, sequence-specific DNA binding
    GO:8134; transcription factor binding
    GO:1077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
    And 1 more GO terms
    Show all GO terms

    Homologs of MYC in Model Organisms

    Danio rerio
    myca
    Mus musculus
    Myc
    Rattus norvegicus
    Myc

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Mus musculus is present as Myc
    GenAge human genes
    • This gene is present as MYC

    External links

    OMIM
    190080
    Ensembl
    ENSG00000136997
    Entrez Gene
    4609
    UniGene
    202453
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MYC
    GeneCards
    MYC