Cell Senescence Entries for MVK

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
IMR-90, MRC-5, HEK293T
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    MVK Gene Information

    HGNC symbol
    MVK 
    Aliases
    MK; LRBP; MVLK; POROK3 
    Common name
    mevalonate kinase 
    Entrez Id
    4598
    Description
    This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

    MVK Ontologies

    Gene Ontology
    Process: GO:6695; cholesterol biosynthetic process
    GO:19287; isopentenyl diphosphate biosynthetic process, mevalonate pathway
    GO:8299; isoprenoid biosynthetic process
    GO:50728; negative regulation of inflammatory response
    GO:16310; phosphorylation
    Cellular component: GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:5777; peroxisome
    Function: GO:5524; ATP binding
    GO:42802; identical protein binding
    GO:4496; mevalonate kinase activity
    GO:5515; protein binding
    Show all GO terms

    Homologs of MVK in Model Organisms

    Caenorhabditis elegans
    mvk-1
    Danio rerio
    mvk
    Drosophila melanogaster
    CG16804
    Mus musculus
    Mvk
    Rattus norvegicus
    Mvk
    Saccharomyces cerevisiae
    ERG12
    Schizosaccharomyces pombe
    erg12

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as mvk-1

    External links

    OMIM
    251170
    Ensembl
    ENSG00000110921
    Entrez Gene
    4598
    UniGene
    130607
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MVK
    GeneCards
    MVK