Cell Senescence Entries for MORF4

Cell Types
Fibrosarcoma
Cell Lines
HT1080, A9
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Overexpression of MORF4 induced a senescent-like phenotype in fibrosarcoma-derived cells, including senescence-specific morphological changes and increased SA-beta-galactosidase activity.
Primary Reference

    MORF4 Gene Information

    HGNC symbol
    MORF4 
    Aliases
    CSR; SEN; CSRB; SEN1 
    Common name
    mortality factor 4 (pseudogene) 
    Entrez Id
    10934
    Description
    Cellular senescence, the terminal nondividing state that normal cells enter following completion of their proliferative potential, is the dominant phenotype in hybrids of normal and immortal cells. Fusions of immortal human cell lines with each other have led to their assignment to 1 of several complementation groups. MORF4 is a gene on chromosome 4 that induces a senescent-like phenotype in cell lines assigned to complementation group B.[supplied by OMIM, Apr 2004]

    MORF4 Ontologies

    Gene Ontology
    Process:
    Cellular component:
    Function:
    Show all GO terms

    Homologs of MORF4 in Model Organisms

    No homologs found

    External links

    OMIM
    116960
    Ensembl
    Entrez Gene
    10934
    UniGene
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MORF4
    GeneCards
    MORF4