Cell Senescence Entries for MECP2

Cell Types
Mesenchymal stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Partial silencing of MECP2 in human mesenchymal stem cells induced a significant shift of cells from the S-phase towards the G(1) phase, accompanied by a reduction of apoptosis, triggering of senescence, decreased telomerase activity and the down-regulation of genes involved in maintaining stem cell properties.
Primary Reference

    MECP2 Gene Information

    HGNC symbol
    MECP2 
    Aliases
    RS; RTS; RTT; PPMX; MRX16; MRX79; MRXSL; AUTSX3; MRXS13 
    Common name
    methyl-CpG binding protein 2 
    Entrez Id
    4204
    Description
    DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]

    MECP2 Ontologies

    Gene Ontology
    Process: GO:8344; adult locomotory behavior
    GO:1662; behavioral fear response
    GO:32048; cardiolipin metabolic process
    GO:50432; catecholamine secretion
    GO:6576; cellular biogenic amine metabolic process
    GO:21549; cerebellum development
    GO:6342; chromatin silencing
    GO:16358; dendrite development
    GO:60079; excitatory postsynaptic potential
    GO:8211; glucocorticoid metabolic process
    GO:6541; glutamine metabolic process
    And 39 more GO terms
    Cellular component: GO:5813; centrosome
    GO:5829; cytosol
    GO:5615; extracellular space
    GO:930; gamma-tubulin complex
    GO:792; heterochromatin
    GO:5739; mitochondrion
    GO:5634; nucleus
    GO:98794; postsynapse
    Function: GO:3677; DNA binding
    GO:3723; RNA binding
    GO:3682; chromatin binding
    GO:10385; double-stranded methylated DNA binding
    GO:42826; histone deacetylase binding
    GO:3729; mRNA binding
    GO:8327; methyl-CpG binding
    GO:47485; protein N-terminus binding
    GO:5515; protein binding
    GO:19904; protein domain specific binding
    GO:35197; siRNA binding
    And 4 more GO terms
    Show all GO terms

    Homologs of MECP2 in Model Organisms

    Danio rerio
    mecp2
    Mus musculus
    Mecp2
    Rattus norvegicus
    Mecp2

    External links

    OMIM
    300005
    Ensembl
    ENSG00000169057
    Entrez Gene
    4204
    UniGene
    200716
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MECP2
    GeneCards
    MECP2