Cell Senescence Entries for MCL1

Cell Types
Colon cancer
Cell Lines
HCT116
Cancer Cell?
Yes
Method
Overexpression, Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Observations
Overexpression of MCL1 in p53+ cell lines inhibited chemotherapy-induced senescence. Conversely, downregulation of Mcl-1 resulted in sensitivity to chemotherapy-induced senescence. Surprisingly, downregulation of MCL1 in p53- cells restored chemotherapy-induced senescence to similar levels as p53+ cells.
Primary Reference

    MCL1 Gene Information

    HGNC symbol
    MCL1 
    Aliases
    TM; EAT; MCL1L; MCL1S; Mcl-1; BCL2L3; MCL1-ES; bcl2-L-3; mcl1/EAT 
    Common name
    MCL1, BCL2 family apoptosis regulator 
    Entrez Id
    4170
    Description
    This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]

    MCL1 Ontologies

    Gene Ontology
    Process: GO:8637; apoptotic mitochondrial changes
    GO:1709; cell fate determination
    GO:19725; cellular homeostasis
    GO:97192; extrinsic apoptotic signaling pathway in absence of ligand
    GO:8630; intrinsic apoptotic signaling pathway in response to DNA damage
    GO:7275; multicellular organism development
    GO:2000811; negative regulation of anoikis
    GO:43066; negative regulation of apoptotic process
    GO:10507; negative regulation of autophagy
    GO:2001240; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
    GO:1903378; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
    And 4 more GO terms
    Cellular component: GO:97136; Bcl-2 family protein complex
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:16021; integral component of membrane
    GO:16020; membrane
    GO:5759; mitochondrial matrix
    GO:5741; mitochondrial outer membrane
    GO:5739; mitochondrion
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:51434; BH3 domain binding
    GO:5515; protein binding
    GO:15266; protein channel activity
    GO:46982; protein heterodimerization activity
    Show all GO terms

    Homologs of MCL1 in Model Organisms

    Danio rerio
    mcl1a
    Mus musculus
    Mcl1
    Rattus norvegicus
    Mcl1

    External links

    OMIM
    159552
    Ensembl
    ENSG00000143384
    Entrez Gene
    4170
    UniGene
    632486
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MCL1
    GeneCards
    MCL1