Cell Senescence Entries for MAPKAPK5

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockout
Type of senescence
Oncogene-induced
Senescence Effect
Promotes
Observations
Knockout of PARK (MAPKAPK5) inhibited ras-induced senescence in human foreskin fibroblasts (BJ cells) and promoted oncogenic transformation. This prevented proliferative arrest and the accumulation of SA-beta-galactosidase.
Primary Reference

    MAPKAPK5 Gene Information

    HGNC symbol
    MAPKAPK5 
    Aliases
    MK5; MK-5; PRAK; MAPKAP-K5 
    Common name
    mitogen-activated protein kinase-activated protein kinase 5 
    Entrez Id
    8550
    Description
    The protein encoded by this gene is a tumor suppressor and member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. The encoded protein is found in the nucleus but translocates to the cytoplasm upon phosphorylation and activation. This kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2012]

    MAPKAPK5 Ontologies

    Gene Ontology
    Process: GO:165; MAPK cascade
    GO:7265; Ras protein signal transduction
    GO:187; activation of MAPK activity
    GO:7166; cell surface receptor signaling pathway
    GO:32007; negative regulation of TOR signaling
    GO:18105; peptidyl-serine phosphorylation
    GO:51973; positive regulation of telomerase activity
    GO:1904355; positive regulation of telomere capping
    GO:32212; positive regulation of telomere maintenance via telomerase
    GO:46777; protein autophosphorylation
    GO:1901796; regulation of signal transduction by p53 class mediator
    And 4 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:5524; ATP binding
    GO:4708; MAP kinase kinase activity
    GO:9931; calcium-dependent protein serine/threonine kinase activity
    GO:5516; calmodulin binding
    GO:4683; calmodulin-dependent protein kinase activity
    GO:2039; p53 binding
    GO:5515; protein binding
    GO:4674; protein serine/threonine kinase activity
    Show all GO terms

    Homologs of MAPKAPK5 in Model Organisms

    Danio rerio
    mapkapk5
    Mus musculus
    Mapkapk5
    Rattus norvegicus
    Mapkapk5

    External links

    OMIM
    606723
    Ensembl
    ENSG00000089022
    Entrez Gene
    8550
    UniGene
    333120
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MAPKAPK5
    GeneCards
    MAPKAPK5