The MAPK14 gene and its putative association with human ageing

Cell Senescence Entries for MAPK14

Cell Types: Lung fibroblast
Cell Lines: MRC-5, WI-38
Cancer Cell?: No
Method: Knockout
Type of senescence: Replicative, Stress-induced
Senescence Effect: Induces
Primary Reference: Iwasa et al. (2003) Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells 8(2)131-44 (PubMed)

HGNC symbol: MAPK14
Aliases: CSBP1; CSBP2; CSPB1; Mxi2; p38; PRKM14; PRKM15
Common name: mitogen-activated protein kinase 14
Entrez Id: 1432
Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

Gene Ontology

Process:	GO:6468; protein phosphorylation GO:16310; phosphorylation GO:165; MAPK cascade GO:6915; apoptotic process GO:6357; regulation of transcription by RNA polymerase II GO:38066; p38MAPK cascade GO:35556; intracellular signal transduction GO:98586; cellular response to virus GO:10628; positive regulation of gene expression GO:6935; chemotaxis GO:7165; signal transduction
	And 55 more GO terms

Cellular component:	GO:5737; cytoplasm GO:5634; nucleus GO:16607; nuclear speck GO:5829; cytosol GO:5576; extracellular region GO:5654; nucleoplasm GO:34774; secretory granule lumen GO:1904813; ficolin-1-rich granule lumen GO:922; spindle pole GO:5739; mitochondrion GO:98978; glutamatergic synapse
	And 1 more GO terms

Function:	GO:166; nucleotide binding GO:4672; protein kinase activity GO:4674; protein serine/threonine kinase activity GO:4712; protein serine/threonine/tyrosine kinase activity GO:5524; ATP binding GO:16301; kinase activity GO:16740; transferase activity GO:106310; protein serine kinase activity GO:4707; MAP kinase activity GO:5515; protein binding GO:19903; protein phosphatase binding
	And 5 more GO terms

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