Cell Senescence Entries for MAPK14

Cell Types
Lung fibroblast
Cell Lines
WI-38, MRC-5
Cancer Cell?
No
Method
Knockout
Type of senescence
Stress-induced, Replicative
Senescence Effect
Promotes
Observations
Knockout of p38 (MAPK14) with a specific inhibitor (SB203580) in lung fibroblasts inhibited senescence. 80% of cells with inhibited p38 showed BrdU incorporation. There was also a large decrease in SA-beta-galactosidase activity and the cells changed from the flat enlarged morphology associated with senescence to a spindle shaped one.
Primary Reference

    MAPK14 Gene Information

    HGNC symbol
    MAPK14 
    Aliases
    RK; p38; CSBP; EXIP; Mxi2; CSBP1; CSBP2; CSPB1; PRKM14; PRKM15; SAPK2A; p38ALPHA 
    Common name
    mitogen-activated protein kinase 14 
    Entrez Id
    1432
    Description
    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

    MAPK14 Ontologies

    Gene Ontology
    Process: GO:70935; 3'-UTR-mediated mRNA stabilization
    GO:77; DNA damage checkpoint
    GO:7265; Ras protein signal transduction
    GO:187; activation of MAPK activity
    GO:1525; angiogenesis
    GO:6915; apoptotic process
    GO:1502; cartilage condensation
    GO:902; cell morphogenesis
    GO:7166; cell surface receptor signaling pathway
    GO:71479; cellular response to ionizing radiation
    GO:71222; cellular response to lipopolysaccharide
    And 50 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:70062; extracellular exosome
    GO:5576; extracellular region
    GO:1904813; ficolin-1-rich granule lumen
    GO:5739; mitochondrion
    GO:16607; nuclear speck
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:34774; secretory granule lumen
    GO:922; spindle pole
    And 1 more GO terms
    Function: GO:5524; ATP binding
    GO:4707; MAP kinase activity
    GO:4708; MAP kinase kinase activity
    GO:51525; NFAT protein binding
    GO:19899; enzyme binding
    GO:48273; mitogen-activated protein kinase p38 binding
    GO:5515; protein binding
    GO:19903; protein phosphatase binding
    GO:4674; protein serine/threonine kinase activity
    Show all GO terms

    Homologs of MAPK14 in Model Organisms

    Danio rerio
    mapk14b
    Mus musculus
    Mapk14
    Rattus norvegicus
    Mapk14

    In other databases

    GenAge human genes
    • This gene is present as MAPK14

    External links

    OMIM
    600289
    Ensembl
    ENSG00000112062
    Entrez Gene
    1432
    UniGene
    485233
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MAPK14
    GeneCards
    MAPK14