Cell Senescence Entries for MAP3K7

Cell Types
Lung fibroblast, Embryonic kidney
Cell Lines
IMR-90, MRC-5, HEK293T
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    MAP3K7 Gene Information

    HGNC symbol
    MAP3K7 
    Aliases
    CSCF; FMD2; TAK1; MEKK7; TGF1a 
    Common name
    mitogen-activated protein kinase kinase kinase 7 
    Entrez Id
    6885
    Description
    The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

    MAP3K7 Ontologies

    Gene Ontology
    Process: GO:38095; Fc-epsilon receptor signaling pathway
    GO:7249; I-kappaB kinase/NF-kappaB signaling
    GO:7252; I-kappaB phosphorylation
    GO:7254; JNK cascade
    GO:2755; MyD88-dependent toll-like receptor signaling pathway
    GO:50852; T cell receptor signaling pathway
    GO:7223; Wnt signaling pathway, calcium modulating pathway
    GO:187; activation of MAPK activity
    GO:186; activation of MAPKK activity
    GO:7250; activation of NF-kappaB-inducing kinase activity
    GO:43276; anoikis
    And 15 more GO terms
    Cellular component: GO:5671; Ada2/Gcn5/Ada3 transcription activator complex
    GO:8385; IkappaB kinase complex
    GO:5829; cytosol
    GO:10008; endosome membrane
    GO:5634; nucleus
    GO:5886; plasma membrane
    Function: GO:5524; ATP binding
    GO:4709; MAP kinase kinase kinase activity
    GO:42802; identical protein binding
    GO:287; magnesium ion binding
    GO:5515; protein binding
    GO:4672; protein kinase activity
    GO:4674; protein serine/threonine kinase activity
    GO:97110; scaffold protein binding
    Show all GO terms

    Homologs of MAP3K7 in Model Organisms

    Caenorhabditis elegans
    CELE_Y105C5A.24
    Danio rerio
    map3k7
    Drosophila melanogaster
    Tak1
    Mus musculus
    Map3k7
    Rattus norvegicus
    Map3k7

    In other databases

    LongevityMap
    • This gene is present as MAP3K7

    External links

    OMIM
    602614
    Ensembl
    ENSG00000135341
    Entrez Gene
    6885
    UniGene
    594838
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MAP3K7
    GeneCards
    MAP3K7