Cell Senescence Entries for MAP2K7

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
IMR-90, MRC-5, HEK293T
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    MAP2K7 Gene Information

    HGNC symbol
    MAP2K7 
    Aliases
    MEK; MKK7; JNKK2; MEK; 7; MAPKK7; PRKMK7; SAPKK4; SAPKK-4 
    Common name
    mitogen-activated protein kinase kinase 7 
    Entrez Id
    5609
    Description
    The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

    MAP2K7 Ontologies

    Gene Ontology
    Process: GO:38095; Fc-epsilon receptor signaling pathway
    GO:7254; JNK cascade
    GO:7257; activation of JUN kinase activity
    GO:6915; apoptotic process
    GO:18108; peptidyl-tyrosine phosphorylation
    GO:51973; positive regulation of telomerase activity
    GO:1904355; positive regulation of telomere capping
    GO:32212; positive regulation of telomere maintenance via telomerase
    GO:35897; proteolysis in other organism
    GO:9411; response to UV
    GO:9408; response to heat
    And 5 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5634; nucleus
    Function: GO:5524; ATP binding
    GO:4708; MAP kinase kinase activity
    GO:19899; enzyme binding
    GO:287; magnesium ion binding
    GO:5515; protein binding
    GO:19901; protein kinase binding
    GO:19903; protein phosphatase binding
    GO:4713; protein tyrosine kinase activity
    GO:4702; signal transducer, downstream of receptor, with serine/threonine kinase activity
    Show all GO terms

    Homologs of MAP2K7 in Model Organisms

    Caenorhabditis elegans
    mek-1
    Danio rerio
    map2k7
    Mus musculus
    Map2k7
    Rattus norvegicus
    Map2k7

    In other databases

    GenDR gene manipulations
    • A homolog of this gene for Caenorhabditis elegans is present as mek-1

    External links

    OMIM
    603014
    Ensembl
    ENSG00000076984
    Entrez Gene
    5609
    UniGene
    531754
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MAP2K7
    GeneCards
    MAP2K7