Cell Senescence Entries for MAP2K6

Cell Types
Osteosarcoma
Cell Lines
U2OS
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Expression of activated MKK6 (MAP2K6) induced morphological, biochemical, and genetic markers of cellular senescence, including permanent cell cycle arrest, up-regulation of p21, increased SA-beta-galactosidase activity, and lipofuscin-associated autofluorescence.
Primary Reference

    MAP2K6 Gene Information

    HGNC symbol
    MAP2K6 
    Aliases
    MEK6; MKK6; MAPKK6; PRKMK6; SAPKK3; SAPKK-3 
    Common name
    mitogen-activated protein kinase kinase 6 
    Entrez Id
    5608
    Description
    This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]

    MAP2K6 Ontologies

    Gene Ontology
    Process: GO:6975; DNA damage induced protein phosphorylation
    GO:165; MAPK cascade
    GO:187; activation of MAPK activity
    GO:6915; apoptotic process
    GO:60048; cardiac muscle contraction
    GO:7050; cell cycle arrest
    GO:72709; cellular response to sorbitol
    GO:70423; nucleotide-binding oligomerization domain containing signaling pathway
    GO:22602; ovulation cycle process
    GO:18108; peptidyl-tyrosine phosphorylation
    GO:43065; positive regulation of apoptotic process
    And 9 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:5856; cytoskeleton
    GO:5829; cytosol
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:5524; ATP binding
    GO:4708; MAP kinase kinase activity
    GO:5515; protein binding
    GO:19901; protein kinase binding
    GO:4674; protein serine/threonine kinase activity
    GO:4713; protein tyrosine kinase activity
    GO:4702; signal transducer, downstream of receptor, with serine/threonine kinase activity
    Show all GO terms

    Homologs of MAP2K6 in Model Organisms

    Danio rerio
    map2k6
    Drosophila melanogaster
    lic
    Mus musculus
    Map2k6
    Rattus norvegicus
    Map2k6

    External links

    OMIM
    601254
    Ensembl
    ENSG00000108984
    Entrez Gene
    5608
    UniGene
    49329
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MAP2K6
    GeneCards
    MAP2K6