Cell Senescence Entries for MAP2K2

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Promotes
Observations
Activated MEK (MAP2K2) caused cell cycle arrest, a dramatic reduction in BrdU incorporation, altered expression of cell-cycle proteins, upregulation of senescence markers p53, p16, and p21, and increased SA-beta-galactosidase activity. MEK-arrested cells did not exhibit senescent morphological changes and instead kept a small and refractile morphology.
Primary Reference

    MAP2K2 Gene Information

    HGNC symbol
    MAP2K2 
    Aliases
    CFC4; MEK2; MKK2; MAPKK2; PRKMK2 
    Common name
    mitogen-activated protein kinase kinase 2 
    Entrez Id
    5605
    Description
    The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]

    MAP2K2 Ontologies

    Gene Ontology
    Process: GO:70371; ERK1 and ERK2 cascade
    GO:165; MAPK cascade
    GO:187; activation of MAPK activity
    GO:10629; negative regulation of gene expression
    GO:36289; peptidyl-serine autophosphorylation
    GO:18108; peptidyl-tyrosine phosphorylation
    GO:70374; positive regulation of ERK1 and ERK2 cascade
    GO:1903800; positive regulation of production of miRNAs involved in gene silencing by miRNA
    GO:71902; positive regulation of protein serine/threonine kinase activity
    GO:45893; positive regulation of transcription, DNA-templated
    GO:35897; proteolysis in other organism
    And 4 more GO terms
    Cellular component: GO:5794; Golgi apparatus
    GO:5911; cell-cell junction
    GO:9898; cytoplasmic side of plasma membrane
    GO:5829; cytosol
    GO:5769; early endosome
    GO:5783; endoplasmic reticulum
    GO:5576; extracellular region
    GO:5925; focal adhesion
    GO:5770; late endosome
    GO:5874; microtubule
    GO:5739; mitochondrion
    And 5 more GO terms
    Function: GO:5524; ATP binding
    GO:4708; MAP kinase kinase activity
    GO:30165; PDZ domain binding
    GO:46872; metal ion binding
    GO:5515; protein binding
    GO:43539; protein serine/threonine kinase activator activity
    GO:4674; protein serine/threonine kinase activity
    GO:4712; protein serine/threonine/tyrosine kinase activity
    GO:4713; protein tyrosine kinase activity
    GO:97110; scaffold protein binding
    GO:4702; signal transducer, downstream of receptor, with serine/threonine kinase activity
    And 1 more GO terms
    Show all GO terms

    Homologs of MAP2K2 in Model Organisms

    Danio rerio
    map2k2b
    Drosophila melanogaster
    Dsor1
    Mus musculus
    Map2k2
    Rattus norvegicus
    Map2k2
    Saccharomyces cerevisiae
    STE7

    External links

    OMIM
    601263
    Ensembl
    ENSG00000126934
    Entrez Gene
    5605
    UniGene
    465627
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MAP2K2
    GeneCards
    MAP2K2