Cell Senescence Entries for MAP2K1

Cell Types
Intestinal epithelial
Cell Lines
HIEC-6
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
Constitutive expression of MEK1 (MAP2K1) caused cells to stop proliferating and become arrested in the G0/G1 phase. This was accompanied by a flatter and enlarged cell morphology, an increase in SA-beta-galactosidase activity and an increase in cellular senescence markers, including p21, p16 and p53.
Primary Reference

    MAP2K1 Gene Information

    HGNC symbol
    MAP2K1 
    Aliases
    CFC3; MEK1; MKK1; MAPKK1; PRKMK1 
    Common name
    mitogen-activated protein kinase kinase 1 
    Entrez Id
    5604
    Description
    The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]

    MAP2K1 Ontologies

    Gene Ontology
    Process: GO:60020; Bergmann glial cell differentiation
    GO:70371; ERK1 and ERK2 cascade
    GO:165; MAPK cascade
    GO:187; activation of MAPK activity
    GO:7050; cell cycle arrest
    GO:48870; cell motility
    GO:90398; cellular senescence
    GO:21697; cerebellar cortex formation
    GO:6935; chemotaxis
    GO:60502; epithelial cell proliferation involved in lung morphogenesis
    GO:60324; face development
    And 25 more GO terms
    Cellular component: GO:5794; Golgi apparatus
    GO:5829; cytosol
    GO:5769; early endosome
    GO:5783; endoplasmic reticulum
    GO:70062; extracellular exosome
    GO:5925; focal adhesion
    GO:5770; late endosome
    GO:5815; microtubule organizing center
    GO:5739; mitochondrion
    GO:5634; nucleus
    GO:5886; plasma membrane
    And 1 more GO terms
    Function: GO:5524; ATP binding
    GO:4708; MAP kinase kinase activity
    GO:8022; protein C-terminus binding
    GO:47485; protein N-terminus binding
    GO:5515; protein binding
    GO:4672; protein kinase activity
    GO:43539; protein serine/threonine kinase activator activity
    GO:4674; protein serine/threonine kinase activity
    GO:4712; protein serine/threonine/tyrosine kinase activity
    GO:4713; protein tyrosine kinase activity
    GO:4728; signal transducer, downstream of receptor, with protein tyrosine phosphatase activity
    And 2 more GO terms
    Show all GO terms

    Homologs of MAP2K1 in Model Organisms

    Caenorhabditis elegans
    mek-2
    Danio rerio
    map2k1
    Mus musculus
    Map2k1
    Rattus norvegicus
    Map2k1
    Schizosaccharomyces pombe
    byr1

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as mek-2
    LongevityMap
    • This gene is present as MAP2K1

    External links

    OMIM
    176872
    Ensembl
    ENSG00000169032
    Entrez Gene
    5604
    UniGene
    145442
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MAP2K1
    GeneCards
    MAP2K1