Cell Senescence Entries for MAGOHB

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Observations
Functional studies were performed by silencing nine genes in young cells, which demonstrated that RNA interference-mediated knockdown of P3H1, LIMA1, MAGOH and MAGOHB induced a premature senescent phenotype in IMR-90 cells.
Primary Reference

    MAGOHB Gene Information

    HGNC symbol
    MAGOHB 
    Aliases
    MGN2; mago; magoh 
    Common name
    mago homolog B, exon junction complex core component 
    Entrez Id
    55110
    Description

    MAGOHB Ontologies

    Gene Ontology
    Process: GO:6405; RNA export from nucleus
    GO:8380; RNA splicing
    GO:31124; mRNA 3'-end processing
    GO:6406; mRNA export from nucleus
    GO:398; mRNA splicing, via spliceosome
    GO:184; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
    GO:6369; termination of RNA polymerase II transcription
    Cellular component: GO:71013; catalytic step 2 spliceosome
    GO:35145; exon-exon junction complex
    GO:43025; neuronal cell body
    GO:5654; nucleoplasm
    Function: GO:3723; RNA binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of MAGOHB in Model Organisms

    Danio rerio
    magoh
    Drosophila melanogaster
    mago
    Rattus norvegicus
    Magohb
    Schizosaccharomyces pombe
    mnh1

    External links

    OMIM
    Ensembl
    ENSG00000111196
    Entrez Gene
    55110
    UniGene
    104650
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MAGOHB
    GeneCards
    MAGOHB