Cell Senescence Entries for MAGOH

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced, Replicative
Senescence Effect
Inhibits
Observations
Functional studies were performed by silencing nine genes in young cells, which demonstrated that RNA interference-mediated knockdown of P3H1, LIMA1, MAGOH and MAGOHB induced a premature senescent phenotype in IMR-90 cells.
Primary Reference

    MAGOH Gene Information

    HGNC symbol
    MAGOH 
    Aliases
    MAGOH1; MAGOHA 
    Common name
    mago homolog, exon junction complex core component 
    Entrez Id
    4116
    Description
    Drosophila that have mutations in their mago nashi (grandchildless) gene produce progeny with defects in germplasm assembly and germline development. This gene encodes the mammalian mago nashi homolog. In mammals, mRNA expression is not limited to the germ plasm, but is expressed ubiquitously in adult tissues and can be induced by serum stimulation of quiescent fibroblasts. [provided by RefSeq, Jul 2008]

    MAGOH Ontologies

    Gene Ontology
    Process: GO:6405; RNA export from nucleus
    GO:31124; mRNA 3'-end processing
    GO:6406; mRNA export from nucleus
    GO:398; mRNA splicing, via spliceosome
    GO:184; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
    GO:381; regulation of alternative mRNA splicing, via spliceosome
    GO:6417; regulation of translation
    GO:6369; termination of RNA polymerase II transcription
    Cellular component: GO:71013; catalytic step 2 spliceosome
    GO:5737; cytoplasm
    GO:35145; exon-exon junction complex
    GO:16607; nuclear speck
    GO:5654; nucleoplasm
    GO:5634; nucleus
    Function: GO:3723; RNA binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of MAGOH in Model Organisms

    Caenorhabditis elegans
    mag-1
    Mus musculus
    Magoh
    Rattus norvegicus
    Magoh

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Caenorhabditis elegans is present as mag-1

    External links

    OMIM
    602603
    Ensembl
    ENSG00000162385
    Entrez Gene
    4116
    UniGene
    421576
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MAGOH
    GeneCards
    MAGOH