Cell Senescence Entries for MAGEA2

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Observations
Overexpression of MAGEA2 inhibited ras-induced cellular senescence and increased proliferation in human foreskin fibroblasts.
Primary Reference

    MAGEA2 Gene Information

    HGNC symbol
    MAGEA2 
    Aliases
    CT1.2; MAGE2; MAGEA2A 
    Common name
    MAGE family member A2 
    Entrez Id
    4101
    Description
    This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. This gene has two identical copies at different loci. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

    MAGEA2 Ontologies

    Gene Ontology
    Process: GO:44257; cellular protein catabolic process
    GO:90398; cellular senescence
    GO:1901984; negative regulation of protein acetylation
    GO:33234; negative regulation of protein sumoylation
    GO:122; negative regulation of transcription from RNA polymerase II promoter
    GO:51443; positive regulation of ubiquitin-protein transferase activity
    GO:72331; signal transduction by p53 class mediator
    GO:6351; transcription, DNA-templated
    Cellular component: GO:16605; PML body
    GO:5634; nucleus
    Function: GO:42826; histone deacetylase binding
    GO:5515; protein binding
    GO:70491; repressing transcription factor binding
    GO:31625; ubiquitin protein ligase binding
    Show all GO terms

    Homologs of MAGEA2 in Model Organisms

    No homologs found

    External links

    OMIM
    300173
    Ensembl
    ENSG00000268606
    Entrez Gene
    4101
    UniGene
    534597
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MAGEA2
    GeneCards
    MAGEA2