Cell Senescence Entries for MAD2L1

Cell Types
Breast epithelial, Lung fibroblast
Cell Lines
IMR-90, MCF-10A
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
RNA interference of Mad2 (MAD2L1) induced aneuploidy and premature cellular senescence in human lung fibroblasts. These displayed typical features of senescent cells, including increased SA-beta-galactosidase expression, along with up-regulation of p53, p14 and p21.
Primary Reference

    MAD2L1 Gene Information

    HGNC symbol
    MAD2L1 
    Aliases
    MAD2; HSMAD2 
    Common name
    mitotic arrest deficient 2 like 1 
    Entrez Id
    4085
    Description
    MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]

    MAD2L1 Ontologies

    Gene Ontology
    Process: GO:31145; anaphase-promoting complex-dependent catabolic process
    GO:51301; cell division
    GO:7093; mitotic cell cycle checkpoint
    GO:70; mitotic sister chromatid segregation
    GO:7094; mitotic spindle assembly checkpoint
    GO:43066; negative regulation of apoptotic process
    GO:45930; negative regulation of mitotic cell cycle
    GO:42177; negative regulation of protein catabolic process
    GO:1904667; negative regulation of ubiquitin protein ligase activity
    GO:51436; negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
    GO:90267; positive regulation of mitotic cell cycle spindle assembly checkpoint
    And 5 more GO terms
    Cellular component: GO:777; condensed chromosome kinetochore
    GO:5829; cytosol
    GO:776; kinetochore
    GO:72686; mitotic spindle
    GO:5643; nuclear pore
    GO:5654; nucleoplasm
    GO:5634; nucleus
    GO:48471; perinuclear region of cytoplasm
    GO:922; spindle pole
    Function: GO:42802; identical protein binding
    GO:5515; protein binding
    GO:42803; protein homodimerization activity
    Show all GO terms

    Homologs of MAD2L1 in Model Organisms

    Caenorhabditis elegans
    mdf-2
    Danio rerio
    mad2l1
    Drosophila melanogaster
    mad2
    Mus musculus
    Mad2l1
    Rattus norvegicus
    Mad2l1
    Saccharomyces cerevisiae
    MAD2
    Schizosaccharomyces pombe
    mad2

    In other databases

    GenAge model organism genes
    • A homolog of this gene for Saccharomyces cerevisiae is present as MAD2

    External links

    OMIM
    601467
    Ensembl
    ENSG00000164109
    Entrez Gene
    4085
    UniGene
    591697
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    MAD2L1
    GeneCards
    MAD2L1