Cell Senescence Entries for LIMK1

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
IMR-90, MRC-5, HEK293T
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Promotes
Observations
A library of 200 constitutively activated kinases was screened in order to identify kinases whose constitutive expression decreased cell proliferation and induced expression of senescence markers; p16 and SASP components. A total of 33 kinases showed pro-senescence effects (particularly MAP3K7, PRKCD, and MATK); kinases with strong pro-senescence effects, induced expression of SASP-component genes (e.g. IL1A, IL1B, IL6 and IL8) through activation of an NF-kappaB-dependent transcriptional program. Inhibition of the NF-kappaB, p53, or Rb pathway proved insufficient to prevent kinase-triggered cell cycle arrest.
Primary Reference

    LIMK1 Gene Information

    HGNC symbol
    LIMK1 
    Aliases
    LIMK; LIMK-1 
    Common name
    LIM domain kinase 1 
    Entrez Id
    3984
    Description
    There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011]

    LIMK1 Ontologies

    Gene Ontology
    Process: GO:38096; Fc-gamma receptor signaling pathway involved in phagocytosis
    GO:7266; Rho protein signal transduction
    GO:30036; actin cytoskeleton organization
    GO:51444; negative regulation of ubiquitin-protein transferase activity
    GO:7399; nervous system development
    GO:32233; positive regulation of actin filament bundle assembly
    GO:45773; positive regulation of axon extension
    GO:51496; positive regulation of stress fiber assembly
    GO:6468; protein phosphorylation
    GO:7165; signal transduction
    Cellular component: GO:5794; Golgi apparatus
    GO:5737; cytoplasm
    GO:5829; cytosol
    GO:5925; focal adhesion
    GO:16020; membrane
    GO:43005; neuron projection
    GO:16607; nuclear speck
    GO:5634; nucleus
    Function: GO:5524; ATP binding
    GO:31072; heat shock protein binding
    GO:5515; protein binding
    GO:46982; protein heterodimerization activity
    GO:4672; protein kinase activity
    GO:4674; protein serine/threonine kinase activity
    GO:4871; signal transducer activity
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of LIMK1 in Model Organisms

    Danio rerio
    limk1a
    Mus musculus
    Limk1
    Rattus norvegicus
    Limk1

    External links

    OMIM
    601329
    Ensembl
    ENSG00000106683
    Entrez Gene
    3984
    UniGene
    647035
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    LIMK1
    GeneCards
    LIMK1