Cell Senescence Entries for LIMA1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced, Replicative
Senescence Effect
Inhibits
Observations
Functional studies were performed by silencing nine genes in young cells, which demonstrated that RNA interference-mediated knockdown of P3H1, LIMA1, MAGOH and MAGOHB induced a premature senescent phenotype in IMR-90 cells.
Primary Reference

    LIMA1 Gene Information

    HGNC symbol
    LIMA1 
    Aliases
    EPLIN; SREBP3 
    Common name
    LIM domain and actin binding 1 
    Entrez Id
    51474
    Description
    This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]

    LIMA1 Ontologies

    Gene Ontology
    Process: GO:51017; actin filament bundle assembly
    GO:30835; negative regulation of actin filament depolymerization
    GO:31529; ruffle organization
    Cellular component: GO:15629; actin cytoskeleton
    GO:5903; brush border
    GO:32154; cleavage furrow
    GO:5737; cytoplasm
    GO:5925; focal adhesion
    GO:1725; stress fiber
    Function: GO:51015; actin filament binding
    GO:3785; actin monomer binding
    GO:45296; cadherin binding
    GO:5515; protein binding
    GO:8270; zinc ion binding
    Show all GO terms

    Homologs of LIMA1 in Model Organisms

    Danio rerio
    lima1
    Drosophila melanogaster
    CG33521
    Mus musculus
    Lima1
    Rattus norvegicus
    Lima1

    External links

    OMIM
    608364
    Ensembl
    ENSG00000050405
    Entrez Gene
    51474
    UniGene
    525419
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    LIMA1
    GeneCards
    LIMA1