Cell Senescence Entries for LGALS3

Cell Types
Gastric cancer
Cell Lines
AGS, MKN28, YCC-2, KATO-III, SNU-1, SNU-5, SNU-16, SNU-216, SNU-601, SNU-638, SNU-668, SNU-719
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
In galectin-3 (LGALS3) depleted gastric cancer cells premature senescence, decreased Skp2 and increased p27 expression was shown.
Primary Reference

    LGALS3 Gene Information

    HGNC symbol
    LGALS3 
    Aliases
    L31; GAL3; MAC2; CBP35; GALBP; GALIG; LGALS2 
    Common name
    galectin 3 
    Entrez Id
    3958
    Description
    This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. The protein exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2014]

    LGALS3 Ontologies

    Gene Ontology
    Process: GO:8380; RNA splicing
    GO:48245; eosinophil chemotaxis
    GO:30855; epithelial cell differentiation
    GO:45087; innate immune response
    GO:6397; mRNA processing
    GO:48246; macrophage chemotaxis
    GO:2548; monocyte chemotaxis
    GO:71674; mononuclear cell migration
    GO:2001189; negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
    GO:50860; negative regulation of T cell receptor signaling pathway
    GO:45806; negative regulation of endocytosis
    And 12 more GO terms
    Cellular component: GO:5737; cytoplasm
    GO:70062; extracellular exosome
    GO:31012; extracellular matrix
    GO:5615; extracellular space
    GO:101003; ficolin-1-rich granule membrane
    GO:1772; immunological synapse
    GO:16020; membrane
    GO:5743; mitochondrial inner membrane
    GO:5634; nucleus
    GO:5886; plasma membrane
    GO:30667; secretory granule membrane
    And 2 more GO terms
    Function: GO:19863; IgE binding
    GO:3723; RNA binding
    GO:30246; carbohydrate binding
    GO:42056; chemoattractant activity
    GO:43236; laminin binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of LGALS3 in Model Organisms

    Caenorhabditis elegans
    lec-7
    Danio rerio
    si:ch211-67f24.5
    Mus musculus
    Lgals3
    Rattus norvegicus
    Lgals3

    In other databases

    GenAge microarray genes
    • This gene is present as LGALS3

    External links

    OMIM
    153619
    Ensembl
    ENSG00000131981
    Entrez Gene
    3958
    UniGene
    531081
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    LGALS3
    GeneCards
    LGALS3