Cell Senescence Entries for KSR2

Cell Types
Embryonic kidney, Retinal pigment epithelial
Cell Lines
hTERT-RPE1, HEK293T
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Unclear
Observations
Using a high-content siRNA screening assay for cell morphology and proliferation measures, 12 senescence-regulating kinases (including KSR2) and their senescence marker signatures were determined, including elevation of SA-beta-galactosidase, DNA damage and p53 or p16 expression.
Primary Reference

    KSR2 Gene Information

    HGNC symbol
    KSR2 
    Aliases
     
    Common name
    kinase suppressor of ras 2 
    Entrez Id
    283455
    Description

    KSR2 Ontologies

    Gene Ontology
    Process: GO:7265; Ras protein signal transduction
    GO:19722; calcium-mediated signaling
    GO:43410; positive regulation of MAPK cascade
    GO:6468; protein phosphorylation
    Cellular component: GO:5829; cytosol
    GO:5886; plasma membrane
    Function: GO:5524; ATP binding
    GO:46872; metal ion binding
    GO:4672; protein kinase activity
    GO:4674; protein serine/threonine kinase activity
    GO:4871; signal transducer activity
    Show all GO terms

    Homologs of KSR2 in Model Organisms

    Danio rerio
    ksr2
    Mus musculus
    Ksr2
    Rattus norvegicus
    Ksr2

    External links

    OMIM
    610737
    Ensembl
    ENSG00000171435
    Entrez Gene
    283455
    UniGene
    375836
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    KSR2
    GeneCards
    KSR2