Cell Senescence Entries for KIAA1524

Cell Types
Gastric cancer
Cell Lines
AGS, HGC-27, KATO-III, BGC-823
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Observations
Depletion of CIP2A (KIAA1524), which is overexpressed in gastric cancer samples, substantially inhibited growth and clonogenic capabilities of tumor cells, and promoted cellular senescence. This effect was independent of the p53 and pRB pathways.
Primary Reference

    KIAA1524 Gene Information

    HGNC symbol
    KIAA1524 
    Aliases
    p90; CIP2A 
    Common name
    KIAA1524 
    Entrez Id
    57650
    Description

    KIAA1524 Ontologies

    Gene Ontology
    Process: GO:2000179; positive regulation of neural precursor cell proliferation
    GO:7283; spermatogenesis
    Cellular component: GO:5737; cytoplasm
    GO:5829; cytosol
    GO:16021; integral component of membrane
    GO:5886; plasma membrane
    Function: GO:45296; cadherin binding
    GO:5515; protein binding
    Show all GO terms

    Homologs of KIAA1524 in Model Organisms

    Danio rerio
    zgc:174160
    Drosophila melanogaster
    CG12702-RA
    Mus musculus
    Kiaa1524
    Rattus norvegicus
    RGD1310335

    External links

    OMIM
    610643
    Ensembl
    ENSG00000163507
    Entrez Gene
    57650
    UniGene
    591308
    1000 Genomes
    1000 Genomes
    HPRD
    GenAtlas
    KIAA1524
    GeneCards
    KIAA1524